Daraasad dhowaan lagu daabacay joornaalka Cellular iyo Molecular Gastroenterology and Hepatology ayaa muujisay in isbeddelka hidda-wadaha ee loo yaqaan ATRX uu horseedi karo khatarta sii kordheysa ee pankreatit iyo kansarka ganaca ee haweenka. Daraasadani waxay calaamad u tahay daahfurkii ugu horreeyay ee arrimaha khatarta hidde-sidaha gaarka ah ee jinsiga ee kansarka ganaca.
The team used a preclinical model to examine the effect of ATRX mutations on the adult pancreas. They deleted the ATRX gene and then studied its effect on kansarka ganaca susceptibility. The team found that the deletion of the ATRX gene in women increased the susceptibility to pancreatitis-related pancreatic damage and accelerated the progression of pancreatic cancer. Ragga, isbedelada ATRX ma kordhiyaan halista waxyeellada ganaca, runtiina waxay yareeyaan horumarka kansarka ganaca.
The team ‘s preclinical results were compared with human samples from the International Cancer Genome Alliance database, which includes whole-genome sequence analysis of 729 patients. Kooxda cilmibaarista waxay ogaadeen in 19% bukaanada ay wataan isbedello dhererka hidda-wadaha ATRX, oo ay kujiraan gobollada aan codeyneyn, oo 70% ay yihiin dumar. In kasta oo isbeddelada badankood aysan u muuqan inay carqaladeynayaan isku xigxiga borotiinka ATRX, isbedelada la saadaaliyay inay saameyn ku yeelan doonaan shaqada ATRX waxay ku dhacaan dumarka.
Saynisyahanka Lawson ahna borofisar ku takhasusay Dr. Chris Pin ayaa yiri, “Kansarka ganaca waa cudur aad u xun oo inta badan lagu ogaado marxalad hore. Bukaanku inta badan kama jawaabaan daawaynta jirta, celceliska cimriga bukaanadana waa ka dib ogaanshaha Wax ka yar 6 bilood. "Pancreatitis waa cudur lagu garto caabuqa xameetida waana mid ka mid ah waxyaabaha ugu muhiimsan ee halista u ah inuu ku dhaco kansarka ganaca. Inkastoo cilmi baaris dheeraad ah loo baahan yahay, haweenka qaba pankreatit waxaa laga yaabaa in maalin loo aqoonsado inay yihiin koox khatar sare leh, iyo isbeddellada hidda-socodka waa in la baaro.
In a follow-up study, Dr. Pin will work with French researchers to study patient buro samples in a new preclinical model. Their goal is to better understand the mechanism of ATRX mutations as a gender-specific risk factor. In order to develop better diagnosis and treatment methods for women carrying this mutation.
