Habka ogaanshaha biomarker ee FoundationOne CDx (F1CDx) waxaa ansixiyay FDA bishii Noofambar 2017 si loo ogaado 324 hiddo-wadaha kala duwan kuwaas oo aqoonsan kara isbeddellada suurtagalka ah ee noocyada 5 ee burooyinka oo ay ku jiraan xasiloonida microsatellite (MSI) culeyska isbeddelka burada. Intaa waxaa dheer, falanqaynta khariidadda molecular Keruis kaliya ma samayn karto baaritaanka hidda-socodka (tirada gen ee la ogaaday waa 592), laakiin sidoo kale waxay sameeyaan baaritaanka borotiinka (CISH, pyrosequencing), baaritaanka MSI, iwm. doorashadu waa sax.
Tijaabooyinku waxay faa'iido u leeyihiin bukaanada leh MSI sare (MSI-H) ama cilladaha dayactirka ee aan isqaban karin (dMMR) aan la daboolin ama burooyinka caloosha ee dheef-shiid kiimikaadka, waxay aqbali karaan pembrolizumab (Keytruda) waxayna yeelan karaan faa'iidooyin suurtagal ah. Ogaanshaha waxa kale oo ay aqoonsan kartaa calamadaha kale ee molecular iyo bartilmaameedyada lagu hago daaweynta. Kahortagga isbaarada difaaca waxay muujiyeen natiijooyin la yaab leh bukaannada qaba kansarka caloosha, gaar ahaan caloosha iyo mindhicirka MSI-H burooyinka. Waxaa lagu dadaalayaa in la kordhiyo jawaabta isbaarada xannibayaasha ee kansarka mindhicirka iyo ganaca iyada oo loo marayo daawaynta isku dhafan. Cilmi-baadhayaashu waxay samaynayaan cilmi-baaris ku saabsan isku-darka daawooyinka immunotherapy-ga badan si ay u fahmaan in ay kicin karaan jawaab-celinta burooyinka aan waxtar u lahayn daaweynta hal wakiil ah. Tijaabooyin bukaan-socod ayaa la qaabeeyey, iyo daawaynta difaaca jirka ayaa hadda lagu daraa kemotherabi iyo daawaynta shucaaca si loo hagaajiyo heerka jawaabta cudurradan.
Daawada saxda ah ayaa noqon doonta mid sii kordheysa sanadaha soo socda, taas oo u oggolaaneysa daaweeyayaasha inay aqoonsadaan biomarkers iyo bartilmaameedyada si wax ku ool ah marka loo eego tiknoolajiyada hadda jira. Iyada oo loo marayo baaritaanka saxda ah-baaritaanka hidde-wadaha, bukaanno badan oo kansar ah ayaa fursad u heli doona inay doortaan daawooyinka ugu habboon ee kansarka ka hortagga kansarka si loo wanaajiyo waxtarka daaweynta, loo sii dheereeyo jiritaanka loona hagaajiyo tayada nolosha.
http://www.onclive.com/web-exclusives/gastrointestinal-cancers-entering-age-of-precision-medicine?p=2
