Janaayo 2023: daroogada nadofaragene firadenovec-vncg (Adstiladrin, Ferring Pharmaceuticals) ay u ansixisay Maamulka Cuntada iyo Dawooyinka ee bukaanada qaangaarka ah ee leh khatarta sare, kansarka aan muruqa lahayn ee kaadiheysta (NMIBC) kaas oo leh kansar ku yaal goobta (CIS) oo leh ama aan lahayn burooyinka papillary.
Daraasadda CS-003 (NCT02773849), xarun badan, tijaabo hal gacan ah oo ay ku jiraan 157 bukaan oo qaba NMIBC khatar sare ah iyo 98 ka mid ah kuwaas oo lahaa CIS kuwaas oo laga yaabo in laga baaro jawaabta, waxtarka ayaa la qiimeeyay. Saddexdii biloodba hal mar ilaa 12 bilood, sunta aan loo dulqaadan karin, ama heerka sare ee NMIBC ee soo noqnoqda, bukaanadu waxay heleen nadofaragene firadenovec-vncg 75 mL intravesical instillation (3 x 1011 viral particles/mL [vp/mL]). Bukaannada waxaa loo oggolaaday inay sii wadaan helitaanka nadofaragene firadenovec-vncg saddexdii biloodba mar ilaa iyo inta aysan jirin soo noqnoqosho heer sare ah.
Jawaabta dhamaystiran (CR) wakhti kasta iyo adkaysiga jawaabtu waxay ahaayeen cabbirada natiijada waxtarka ugu weyn (DoR). Si loogu qalmo CR ahaan, cystoscopy taban oo ay weheliso TURBT, biopsies, iyo cytology kaadida ayaa loo baahnaa. Shan nooc oo kala duwan oo kaadi-qaadis ah ayaa si aan kala sooc lahayn looga soo qaaday bukaannada weli ku jira CR sannad ka dib. Dhexdhexaadka DoR wuxuu ahaa 9.7 bilood (kala duwan: 3, 52+), heerka CR wuxuu ahaa 51% (95% CI: 41%, 61%), iyo 46% bukaanada jawaabaya waxay ku sii jireen CR ugu yaraan hal sano.
Kordhinta hyperglycemia, dheecaanka goobta beerista, triglycerides oo kordha, daal, kaadiheysta kaadiheysta, degdega micturition, creatinine kordhay, hematuria, fosfooraska oo yaraada, qarqaryo, dysuria, iyo pyrexia ayaa ahaa dhibaatooyinka soo noqnoqda (dhacdooyinka 10%), iyo sidoo kale baaritaanka aan caadiga ahayn >15%).
Adigoo isticmaalaya kateetarka kaadida, maamul 75 mL of nadofaragene firadenovec-vncg kaadiheysta hal mar saddexdii biloodba mar iyadoo la uruurinayo 3 x 1011 vp/mL. Waxaa lagula talinayaa in la qaato daawada anticholinergic ka hor inta aan la gelin.
