Dib -u -eegis nidaamsan iyo aniga Sakuraba iyo warbixinno kale oo ka socda Jaamacadda ChicagoNatiijooyinka falanqaynta waxay muujinayaan in bukaannada qaba cudurrada beerka ee daba-dheeraada ay halis sare ugu jiraan kansarka mindhicirka (CRC), xitaa haddii bukaannadan la siiyo beerka beddelka, khatartani weli way jirtaa. (Gastrointestinal Endosc. Nooca khadka tooska ah ee Diseembar 21, 2016)
Sakuraba waxay sheegtay in iyadoo aan loo eegin waxa sababay cudurka beerka, bukaannada qaba cudurka beerka ee joogtada ah waxay leeyihiin halis sare oo ah CRC, halistaasna weli way jirtaa ka dib markii beerka laga tallaalay. Sidaa darteed, bukaanka qaba cudurka beerka ee dabadheeraada waa in la baaro ama lala socdo xoog badan si loo yareeyo halista CRC.
Sakuraba et al. Wuxuu qiimeeyay halista CRC ee bukaannada qaba cudurka beerka ee daba dheeraada ka hor iyo ka dib beerista beerka. Cilmi -baadhayaashu waxay baadheen daraasado ku saabsan halista cudurka beerka ee daba -dheeraada iyo CRC iyada oo loo marayo keydka elektiroonigga ah waxayna baaritaan ku sameeyeen wadarta 55 991 bukaan 50 daraasadood. Sida laga soo xigtay Sakuraba, daraasado ay ku jiraan bukaanada qaba cagaarshow iyo cirrhosis, wadarta guud ee heerka dhacdooyinka caadiga ah (SIR) waxay ahayd 2.06 (95% CI 1.46 ~ 2.90, P <0.0001), iyo kala duwanaansho dhexdhexaad ah (I2 = 49.2%) Tani waa waxay u badan tahay inay ugu wacan tahay kala duwanaanshaha kooxo-hoosaadyada cudurrada iyo xoojinta cilmi-baarista.
Seddex daraasadood ayaa muujiyay in bukaanada qaba cudurka sclerosing cholangitis (PSC) ay leeyihiin halista sii kordheysa ee CRC (SIR = 6.70, 95% CI 3.48-12.91; P <0.0001), iyo heterogeneity dhexdhexaad ah (I2 = 36.3%), Sida iska cad tani waa sabab farqiga u dhexeeya xoojinta cilmi baarista. Daraasadahaas oo ay ku jiraan bukaanno lagu tallaalay beerka, SIR wuxuu ahaa 2.16 (95% CI 1.59 ilaa 2.94, P <0.0001), iyo heterogeneity wuxuu ahaa mid dhexdhexaad ah (I2 = 56.4%).
Marka la eego falanqaynta ta, saamiga cudurada beerka ee is-difaacida la xiriira waxay la xiriirtay halista CRC. Sakuraba ayaa yiri, "Hore waxaa loo maleynayay in bukaannada PSC kaliya ay yeelan doonaan khatarta sii kordheysa ee CRC, laakiin cilmi-baaristeenna waxay muujisay in halista CRC ee bukaannada qaba cudurrada kale ee beerka ee joogtada ah ay sidoo kale kordhin doonto. Isla kororka ayaa aad muhiim u ah. "
Patrick Boland from the Roswell Park Cancer Institute in New York is not a member of the study. He pointed out that most of the patients in the study have cirrhosis, PSC or have received liver transplantation. The risk of CRC in PSC patients is particularly obvious. PSC is associated with inflammatory bowel disease, which is a known risk factor for kansarka mindhicirka, which is also the strongest evidence. However, those who have undergone liver transplantation, especially those with underlying autoimmune diseases, have an increased risk of CRC. Organ transplantation requires the use of immunosuppressive agents, which puts the patient at risk of secondary malignancy for a long time. They have evidence that kidney transplant patients have an increased risk of colon cancer. The data from this study showed that the risk of colon cancer in patients who underwent liver transplantation would be doubled.
Boland waxay sheegtay in natiijooyinkani aysan ahayn wax cusub, maxaa yeelay caabuq iyo tallaal-celinta jirka waa sababaha halista u ah kansarka mindhicirka weyn. Wuxuu aaminsan yahay in baarista walamadka ay qayb ka noqon karto baaritaanka qalliinka ee metastases beerka, gaar ahaan bukaanada qaba PSC. Waxa kale oo uu sheegay in sababta oo ah burooyinka ku dhaca qaybaha kala duwan ee xiidmaha waaweyn ay leeyihiin kala duwanaansho bayoolojiyeed oo kaladuwan, waxaa xiiso leh in daraasad dheeri ah lasameeyo in halista cudurka inta badan ay la xiriirto xiidmaha bidix ama midig.
