Luulyo 2021: Daaweynta CAR T-Cell ee burooyinka adag ayaa lagu ansixiyay Shiinaha oo leh calaamado iyo calaamado gaar ah. Dhawaan, Daaweynta T-Cell-ka Baabuurka waxaa laga baaray kansarrada adag sida:
- Kansarka naasaha
- Kansarka sambabada ee aan unugyadu yarayn
- Kansarka beerka
- Cholangiocarcinoma
- kansarka malawadka
- kansarka caloosha
- Kansarka naasaha
- kansarka hunguriga
- kansarka ganaca
- Oophoroma
- Kansarka xameetida
- Kansarka kaadi mareenka
GARGAARKA GARGAARKA on all these cancers is applicable for patients who have relapsed after some lines of treatment such as surgery, chemotherapy and radiotherapy.
It’s the first GARGAARKA GARGAARKA case around the world that a 5 year old girl named Emily with Leukemia was cured in 2012.
Jimmy Carter, 90, a former US president, announced that melanoma cells had spread to the liver and brain.
Diseembar 6, 2015, oo leh antibody-ka PD-1 iyo shucaaca, unugyada kansarka ee vivo waa la waayay.
6-dii Maarso, 2016, uma baahnin daaweyn loogu talagalay melanoma.
Bishii Diseembar 2, 2018, wuxuu sidoo kale ka soo muuqday aaska Madaxweynihii hore Bush.
Dhammaadkii 2013, immunocytotherapy waxaa lagu qiimeeyay mid ka mid ah tobanka horumar ee tignoolajiyada ugu sareeya ee sanadka ee majaladda Science.
2014, laba shirar tacliineed oo kansar ah oo awood leh, AACR iyo ASCO, ayaa lagu qabtay Maraykanka. Immunotherapy waxay noqotay diiradda tignoolajiyada gees ka gees. Sannadkii 2014, FDA waxay ansixisay liiska nivolumab iyo pembrolizumab.
CAR T Daaweynta unugyada kansarka tayroodhka
In 2015, Movie director Chen Xunqi was diagnosed with undifferentiated kansarka tayroodh, underwent surgery and multiple chemotherapy in Beijing, and gave up chemotherapy;
In 2016, PS score is 3 when he is in hospital, skinny, and decided to try CAR T therapy after two courses to make the buro disappear;
Sannadkii 2017, waxaa la tijaabiyey oo dib loo hubiyey, caadi; sanadka 2018, waxaa la tijaabiyey oo dib loo hubiyey, caadi;
Waa maxay daaweynta CAR T Cell?
Unugyada T-gu waxay galaan unugyada burooyinka, waxay sirayaan unugyada difaaca isbaarada (PD-1, CTLA-4 iyo unugyada kale ee difaaca jirka), waxayna si tartiib tartiib ah u beddelaan unugyada difaaca jirka ee deegaanka ee buro.
CAR-T in T cells kill target tumors and releases cytokines to up-regulate MHC expression and expose tumor antigens. Meanwhile, immune checkpoint antibodies reduce tumor local microenvironment T cell (TIL) inhibition, and infiltrated T cells begin to Start, activate and multiply.
CAR-T & TIL waxay soo saaraan saameyn cluster ah, oo burooyinka u rogaan goob dagaal oo difaac ah, iyagoo dilaya dhamaan noocyada unugyada burooyinka isla markaana u rogaya burooyinka kulul, gebi ahaanba baabi'inaya burooyinka iyo sameynta unugyada xusuusta waxtarka leh ee T, taasoo yareyneysa suurtagalnimada soo noqoshada burooyinka.
Dhibaatooyinka kale ee daaweynta CAR T-Cell ee xaaladaha kansarka adag
25 ka mid ah bukaannada qaba kansar adag, 25 waxay aadeen tijaabooyinka CAR T-Cell:
- qandho sare ayaa laga helay 6 bukaan
- dyspnea iyo calaamadaha sambabada ee 2 bukaan
- 1 bukaan wuxuu lahaa maqaar qalalan iyo buskud
- ma jiro bukaanno kale oo muujiyay cillado aan caadi ahayn.
Kiis A: Bukaanka kansarka sanbabada oo maraya daawaynta CAR T-Cell
In November of 2009, the patient found a left lung mass and underwent radical left kansarka sanbabada radical surgery. Pathology: lung adenocarcinoma;
Laga bilaabo Jannaayo 2013 ilaa Janaayo 2017, saddex metastases oo maskaxda ah ayaa dhacay, qalliin iyo daawaynta shucaaca ayaa si isdaba joog ah loo siiyay kontorool xumo;
Laga bilaabo Maarso 2017 ilaa Sebtembar 2017, dheef-shiid kiimikaadka maskaxda, unugyada mesoCAR-αPD1 ee muujinaya PD-1 antibody ayaa la siiyay lix koorso oo daaweyn ah. Daawaynta ka dib, PR waa la qiimeeyay iyo burooyinka ayaa si weyn u yaraaday oo kaliya qadar yar oo hadhaaga ah.
Kiiska B: Bukaanka kansarka xiniinyaha ee ku socda daawaynta CAR T-cell
Bishii Agoosto ee 2016, bukaanku wuxuu helay tiro badan oo ku jira xiniinyaha saxda ah wuxuuna maray daaweyn qalliin. Pathology: embriyaha rhabdomyosarcoma;
Bishii Maarso ee 2017, dib u eegista PET-CT, waxay ogaatay in peritoneum, omentum, iyo mindhicirku aanay caddayn, iyada oo la tixgelinayo metastases badan oo ku jira daloolka caloosha;
Laga bilaabo Juun ilaa Sebtembar 2017, unugyada mesoCAR-αPD1 ee muujiyay antibody-ga PD-1 ayaa la siiyay 4 jeer. Saameyntu waxay ahayd CR; dhammaan dheef-shiid kiimikaad ee caloosha ayaa iska baxay.
Kiis C: Bukaanka kansarka sanbabada adenosquamous wuxuu helayaa daawaynta CAR T-cell
In November 2017, the left upper lung adenosquamous carcinoma (6.4 “2.9cm) was detected, accompanied by metastasis of the left clavicle and bilateral cervical lymph nodes. He was admitted to hospital for treatment, and Ⅲ and V bone and brain depression occurred after 3 chemotherapy , Side effects are strong. Choose to try immunotherapy oo lagu daray kiimoterabi.
January 2 iyo February 6, 2018, laba faleebooyin unugyada difaaca jirka ayaa la sameeyay, jidhkuna si aad ah ayuu u fiicnaaday, dhibaatooyinka daweynta kiimoterabiga ayaa si tartiib tartiib ah u yaraaday. Dib-u-baaritaanku ma muujin dib-u-qiimeyn buro ama koror ah.
Baadhitaannadii dhammaadkii Febraayo 2018 waxay muujiyeen in nabarrada ku dhaca sambabada ay si weyn hoos ugu dhaceen xaaladdii kansarkana durba waa la xakameeyey.
Kiiska D: Bukaanka kansarka beerka ayaa lagu daaweeyay CAR T-cell
Juun 1, 2017, buro 66mm x 46mm ah ayaa laga helay xagga sare ee sambabada lobe bidix. Juun 15-keedii, waxaa la dhigay Isbitaalka Qalliinka Hepatobiliary ee Oriental si loogu daweeyo. Iyada oo ku saleysan natiijooyinka CT-gu hagayo ka-qaadista daloolada sambabada, qorshe daweyn saddex-hal-hal ah oo isku-darka difaaca unugyada CAR-T, daawaynta la beegsanayo + kemotherabi ayaa la sameeyay. Bishii Luulyo 29, 2017, daawaynta faleebo unug difaaceed ee ugu horeysay ayaa la sameeyay. Faleebo ka dib, jidhku si adag ayuu uga falceliyay. Ka dib markii xaaladdiisu degtay, xaaladdiisu way soo roonaatay markii hore. Ka dib in ka badan lix bilood oo daaweynta difaaca jirka ah oo lagu daray daawaynta la beegsaday, burooyinka jidhku aad ayay u yaraadeen.
Kiiska E: Bukaanka kansarka sanbabada leh ee metastasis maskaxda ayaa maray daawaynta CAR T-cell
On November 26, 2009, a 3.03 “2.39cm tumor was detected in the upper lobe of the left lung, and the upper left lobe was removed directly and completely at an early stage. On January 25, 2013, numbness in the left lower extremity failed to detect a brain metastatic tumor Resection of deep lesions on the screen + targeted therapy with Iressa. 6 In June 2016, a sheet-shaped, abnormally enhanced foci appeared at the junction of the right frontal-parietal lobe for intracranial tumor resection. In 2017, burada maskaxda Deterioration, a tumor of about 3.3 “2.8 cm, appeared in the right parietal lobe, and multiple meningeal metastases and radiotherapy was performed. 3In March 2017, immunotherapy was started. Four times before and after the infusion, the tumor in the brain has improved significantly.
Kiiska F: Bukaanka kansarka tayroodh ee aan kala soocnayn ayaa helay daawaynta CAR T-cell
2016, waxaa laga helay kansarka qanjirka 'thyroid' oo aan la kala soocin. Quine waa nooca ugu xun ee kansarka tayroodhka, waxayna dhakhaatiirtu u sheegeen in nolosha 2 bilood oo kaliya ay hartay. Kadib dhowr daaweyn shucaac ah, waxay lumisay 30 rodol, laakiin jirkeedu ma uusan fiicnayn. Waxay markii dambe diiday inay hesho daaweynta kiimikada. Markii dambe, waxaan u aaday inaan isku dayo tallaalka difaaca jirka. Ka dib 2 faleebo unugyada difaaca jirka, unugyada kansarka ku jira jirka ayaa gebi ahaanba baaba'ay.
Kiiska G: Bukaanka kansarka Hypopharyngeal wuxuu helayaa daaweynta CAR T-cell
Bishii Luulyo 2014, waxaa laga helay kansarka hypopharyngeal, kansarka sacral linary. 2 koorso oo ah kiimoterabiga iyo qalliinka kansarka hypopharyngeal iyo kala goynta qoorta midig. Sannad iyo badh ka dib, wuu soo noqday, ka dibna wuxuu sii waday daaweynta shucaaca, taas oo waxyeellooyinkeeda ay ahaayeen kuwo muuqda oo xaaladdiisa jireed ay aad u liidatay. Janaayo 13, 2016, afar faleebo unug difaac ah ayaa si isdaba joog ah loo helay. Xaaladdu waxay bilowday inay dejiso xaaladduna si weyn ayay u soo roonaatay. Laga soo bilaabo Luulyo ilaa Disembar 2016, shan faleebo unug oo kale ayaa la sameeyay, xaalada jireed si tartiib tartiib ah ayey u fiicnaatay, hurdo caadi ah iyo rabitaanka cuntada. Xaaladda curyaannimo ee sariirta dhowr bilood, iyo muruqyada si tartiib tartiib ah, miisaankiisu wuxuu kordhay 80 kg ilaa 112 kg.
Kiiska H: Bukaanka kansarka naasaha ee bidix ee qaba metastasis maskaxda ayaa helaya daawaynta CAR T-Cell
In January 2014, she was diagnosed with diffuse breast cancer with lung and liver metastases. From January to November 2014, 9 chemotherapy sessions were performed. From June 2015, cancer cells metastasized to the brain, and 11 cranial gamma knife treatments were performed, and the cancer cells spread completely. 3In March 2017, in Hong Kong, received PD-1 treatment and still failed. Beginning in April 2018, we tried CAR-T immunotherapy. After one course of treatment, the effect was remarkable. The swelling of the brain and liver disappeared. The swelling that had spread throughout the lungs was only scattered. Reduced to 1.2.
