Jaamacadda Texas Xarunta Kansarka MD Anderson iyo Shirkadda Takeda Pharmaceutical Limited have entered a restrictive understanding and research consent to develop and market chimeric antigen receptor directed natural killer (CAR NK)- cell treatments.
Fahamka hoostiisa, Takeda waxay marin u heli doontaa marxaladda daawaynta MD Anderson si ay u abuurto oo ay u suuq geyso daawaynta CAR NK-unug ilaa 4 mashruuc, sida lagu muujiyay bayaanka la sameeyay Talaadadii ie 4th ee Febraayo. iyo sida ay uga go'an tahay horumarinta daawaynta unugyada jiilka soo socda, Takeda waa wada-shaqeynta ugu fiican si ay u caawiso kooxdeena horumarinta CAR NK-daawaynta unugyada bukaanka u baahan daawaynta, "ayuu yiri Katy Rezvani, MD, PhD, borofisar ku-tallaalidda unugyada asliga ah iyo daaweynta gacanta iyo MD Anderson.
Daaweyntu waxay leedahay farsamo isbarbardhig ah oo loogu talagalay daaweynta aadka loo yaqaan 'CAR T-cell treatment', oo muujineysa dammaanad weyn oo ku saabsan cudurro badan, iyada oo la soo ururinayo qaar ka mid ah platelet cad oo bukaan ah, iyaga oo lagu qalabeeyo kuwa duuba dusha sare ee diiradda si loola dagaallamo koritaanka khaaska ah ee mawduuca, ka dibna ka dib iyaga mar kale dhiigga bukaanka.
Be that as it may, chemotherapy may leave a few patients without adequate autologous T cells in their blood for treatment with CAR T-cell treatment, while others might not have the opportunity that is required for a lab to create enough T cells, as indicated by the analysts.
Gawaarida NK-unugga gawaarida, oo lagu sameeyay MD Anderson, waxay ka faa'iideysataa unugyada fulinta caadiga ah dhiigga xadhigga. Kooxda ayaa sheegtay in ay oggol tahay jiil daaweyn ah oo aan u baahnayn in si gaar ah loogu sameeyo bukaan kasta - waxaana sii dheer in meesha laga saarayo macquul ahaanshaha ku biirista iyo ka soo horjeedka jirro, taas oo khatar ku ah qaar ka mid ah noocyada T-cell.
The MD Anderson group utilized a retrovirus to bring new qualities into the NK cells: CD19 is added to expand the CAR NK explicitness for B-cell malignancies; interleukin 15 (IL15) is added to draw out the present of the phones in the body; and a CASP9-based “suicide quality” as a sort of security measure, which can be actuated to trigger apoptosis by little atom dimerizers if there is poisonous quality after imbuement.
Ku dhawaaqida fahamka, MD Anderson iyo Takeda waxay carrabka ku adkeeyeen in daawaynta CAR NK-ka-baxsan lagu maamuli karo aagagga bukaan-socodka.
Ilaa iyo hadda, daaweyntu waxay muujisay badbaado: Heerka horumarka I / 2a ee baaritaanka bukaan socodka ee leh dib-u-dhac iyo madax-xannuunno B-cell ah waxay muujiyeen in CD19 CAR NK-daaweynta aysan la xiriirin cilad-darrada sii-deynta cytokine ama neurotoxicity arkay daaweynta CAR-T ee jirta.
Takeda waxay sheegtay inay damacsan yihiin inay bilaabaan baaritaan muhiim ah oo ku saabsan daaweynta CD19 CAR NK-cell sanadka 2021.
Waxaa laga yaabaa inaad jeceshahay inaad akhriso: CAR-NK Daaweynta unugyada
MD Anderson wuxuu helayaa qayb qayb toos ah oo aan lagu qeexin kulamada inay qayb ka yihiin abaabulka, sida madaxbanaanida lakabyada ah ee heshiisyada saafiga ah ee suurtagalka ah, sida lagu muujiyey ku dhawaaqista.
Rezvani wuxuu yiri hadafku waa in la sameeyo daaweyn loo helo bukaanada aakhirkana nolosha wax laga badalo.
“Our vision is to improve upon existing treatments by developing armored CAR NKs that could be administered off-the-shelf in an outpatient setting, enabling more patients to be treated effectively, quickly, and with minimal toxicities,” said Rezvani.
