Abriil 2022: Caadi ahaan, habka wax soo saarka unugyada ee daaweynta CAR T-cell waxay qaadataa sagaal ilaa afar iyo toban maalmood; si kastaba ha ahaatee, cilmi-baarayaasha Jaamacadda Pennsylvania waxay awoodeen inay abuuraan unugyo CAR T ah oo shaqeynaya oo leh waxtarka ka hortagga burooyinka oo la xoojiyay 24 saacadood oo keliya iyagoo isticmaalaya farsamo cusub.
Nooc cusub oo immunotherapy ah oo loo yaqaan autologous CAR T-cell therapies waxay isticmaashaa unugyada difaaca jirka ee T ee bukaanka, waxay ku beddelaan meel ka baxsan jidhka iyagoo ku daraya hidda-wadaha CAR kaas oo ka dhigaya inay muujiyaan reseptors kuwaas oo si fiican u bartilmaameedsada unugyada kansarka, ka dibna dib ugu celisa bukaanka. . Daawayntan, dhinaca kale, waxay caan ku yihiin wakhtiyada dheer ee wax soo saarka, kuwaas oo faragelin kara awoodda unugga si ay u soo celiyaan, sidaas darteedna waxay yareeyaan awoodda daaweynta, iyada oo aan la xusin in bukaannada aadka u xanuunsan ay sii xumaadaan inta ay sugayaan daaweynta. Natiijo ahaan, soo-saareyaasha daawaynta unugyada iswada-taagga ah ayaa mudnaan sare saaray dhimista waqtiga u dhexeeya soo saarista dhiigga iyo dib-u-furidda unugyada oo la beddelay, oo sidoo kale loo yaqaanno wakhtiga xidid-ilaa-xididka.
Daraasada hore ee kiliinikada ee lagu daabacay Nature Biomedical Engineering waxay muujisay in qadarka wakhtiga, agabka, iyo shaqada loo baahan yahay si loo soo saaro unugyada CAR T ay si weyn hoos ugu dhici karto. Sida laga soo xigtay cilmi-baarayaashu, tani waxay si gaar ah faa'iido u yeelan kartaa shakhsiyaadka qaba cudurrada degdega ah iyo goobaha isbitaallada ee leh kheyraad xaddidan.
“While traditional manufacturing approaches for creating CAR T cells that take several days to weeks continue to work for patients with ‘liquid’ cancers like leukaemia, there is still a significant need to reduce the time and cost of producing these complex therapies,” said Dr. Michael Milone, an associate professor of pathology and laboratory medicine and one of the study’s co-leaders. The manufacturing method reported in this study is a testament to the potential to innovate and improve the production of CAR T cell therapies for the benefit of more patients, building on our research from 2018 that reduced the standard manufacturing approach to three days, and now to less than 24 hours.
Cilmi-baadhayaashu waxay ogaadeen in tayada sheyga CAR T, halkii uu ka ahaan lahaa lambarkiisa, uu yahay darawal muhiim ah oo ku guulaysta noocyada xayawaanka. Cilmi baaristoodu waxay muujisay in tiro yar oo tayo sare leh oo CAR T ah oo laga sameeyay meel ka baxsan jidhka iyada oo aan la helin balaadhin la taaban karo ay ka door bidayaan tiro badan oo ah unugyada tayada hoose ee CAR T kuwaas oo si ballaaran loo ballaariyay ka hor intaysan ku noqon bukaanka.
Unugyada T-da waa in loo hawlgeliyo si ay u bataan oo u tarmaan si loogu isticmaalo hababka wax soo saarka ee soo jireenka ah. Isticmaalka hababka injineernimada ee ku salaysan qayb ka mid ah fahamka sida HIV-ga si dabiici ah u saameeya unugyada T, cilmi-baarayaasha Penn waxay awoodeen inay baabi'iyaan tallaabadan habka wax soo saarka. Kooxdu waxay daahrogtay hab toos ah oo hiddo-wadaha loogu gudbiyo unugyada T aan firfircoonayn ee dhawaan laga soo saaray dhiigga. Tani waxay bixisay faa'iidada laba-geesoodka ah ee dedejinta dhammaan habka wax soo saarka iyada oo weli la ilaalinayo awoodda unugyada T. Habkani ma ogola in bukaanku qaado HIV.
Helitaanka bukaan-socodka daawaynta unuggu waa xaddidan tahay kharashka awgeed. Cilmi-baadhayaashu waxay filayaan in iyadoo la dhimayo kharashka iyo wakhtiga la xidhiidha wax-soo-saarka, daawayntan ayaa laga dhigi karaa kharash badan oo waxtar leh, taas oo u oggolaanaysa bukaanno badan inay galaan.
"Habkan cusubi waa mid cajiib ah iyadoo laga yaabo inay awood u yeelato inay caawiso bukaannada aan haddii kale awoodin inay ka faa'iidaystaan Daaweynta unugyada CAR T, sida kuwa qaba kansarka degdega ah, sababtoo ah wakhtiga muhiimka ah ee loo baahan yahay si loo soo saaro daawayntan," ayuu yidhi Dr. Saba Ghassemi, oo ah kaaliyaha cilmi-baarista ee cilmi-nafsiga iyo daawada shaybaadhka iyo hoggaamiye kale oo daraasadda ah. "Dib-u-habayn wax ku ool ah oo unugyada T ee leh CAR ugu yaraan 24 saacadood hab wax soo saar aad u fudud iyada oo aan la kicin unugyada T ama dhaqanka ka baxsan jirka ayaa sidoo kale furaya ikhtiyaarka ballaarinta halka iyo marka daawayntan la soo saaro." Ma aha oo kaliya inay kordhiso awoodda xarumaha wax soo saarka dhexe, laakiin haddii ay sahlan tahay oo joogto ah oo ku filan, waxaa suurtagal ah in la soo saaro daawayntan gudaha bukaanka u dhow, iyada oo wax laga qabanayo caqabadaha badan ee saadka ee xannibaya bixinta daaweyntan waxtarka leh, gaar ahaan kuwa saboolka ah. deegaanka.”
Cilmi-baadhayaashu waxay sheegeen in daraasaddoodu "ay horseed u tahay cilmi-baaris caafimaad oo dheeraad ah si loo fahmo sida unugyada CAR T ee la beddelay ee u shaqeeyaan bukaannada qaba burooyinka gaarka ah iyagoo isticmaalaya xeeladdan la soo gaabiyey."
Iyadoo lala kaashanayo Novartis iyo Isbitaalka Carruurta ee Philadelphia, khubarada Penn waxay hormuud ka ahaayeen cilmi-baarista, horumarinta, iyo tijaabooyinka bukaan-socodka ee daawaynta CAR T ee aasaaska u ah. Novartis ayaa shati ka siisay qaar ka mid ah tignoolajiyada loo adeegsaday baaritaanadan oo ka yimid Jaamacadda Pennsylvania.
