Oktoobar 2021: Maamulka Cuntada iyo Dawooyinka ayaa oggolaaday abemaciclib (Verzenio, Eli Lilly iyo Shirkadda) in combination with endocrine therapy (tamoxifen or an aromatase inhibitor) for adjuvant treatment of adult patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, node-positive, early breast cancer at high risk of recurrence and a Ki-67 score of less than 20%, as determined by an FDA- This is the first CDK 4/6 inhibitor to be approved for breast cancer adjuvant treatment.
Agilent, Inc. ayaa soo gudbisay Ki-67 IHC MIB-1 pharmDx (Dako Omnis), kaas oo ay u oggolaatay FDA sidii wehel ogaanshaha calaamaddan.
Dumarka qaangaarka ah iyo ragga leh HR-positive, HER2-negative, node-positive, resection, kansarka naasaha hore ee leh sifooyin bukaan-socod iyo daaweyn oo waafaqsan khatarta sare ee soo noqoshada cudurku waxay ku lug lahaayeen monarchE (NCT03155997), randomized (1: 1) , summada furan, tijaabinta xarun-kooxeed ee laba-koox ah. Bukaannada waxaa la siiyay 2 sano oo abemaciclib ah oo lagu daray doorashada dhakhtarkooda ee daawaynta caadiga ah ee endocrine ama daaweynta caadiga ah ee endocrine oo keliya.
Badbaadinta cudur-la'aanta ah ee faafa waxay ahayd cabbirka natiijada waxtarka aasaasiga ah (IDFS). Tijaabooyinku waxay heleen horumar la taaban karo oo tirakoobka ah ee IDFS (HR 0.626; 95 boqolkiiba CI: 0.488, 0.803; p=0.0042) bukaanada leh khatarta sare ee soo noqoshada iyo dhibcaha Ki-67 ee ka yar 20% (N=2003). Bukaannada qaata abemaciclib ee tamoxifen ama aromatase inhibitor ah waxay lahaayeen IDFS boqolkiiba 86.1 (95 boqolkiiba CI: 82.8, 88.8) bilaha 36, halka kuwa qaata tamoxifen ama aromatase inhibitor ay lahaayeen IDFS boqolkiiba 79.0 (95 boqolkiiba CI: 75.3, 82.3). ). Waqtiga falanqaynta IDFS, xogta guud ee badbaadada lama dhamaystirin.
Shuban, caabuq, neutropenia, daal, leukopenia, lallabbo, dhiig-yaraan, iyo madax-xanuun ayaa ahaa waxyeellooyinka ugu badan (20%).
Qiyaasta bilowga ah ee lagu taliyey ee abemaciclib waa 150 mg laba jeer maalin kasta oo lagu daro tamoxifen ama aromatase inhibitor 2 sano ama ilaa uu cudurku soo noqnoqonayo ama suntan aan loo dulqaadan karin, hadba kii soo hormara.
