Koox cilmi baaris ah oo ka tirsan Machadka Cilmi-baarista Kansarka (CSI) ee Jaamacadda Qaranka ee Singapore waxay soo saareen dawada peptide-ga cusub ee loo yaqaan FFW taasoo ka hortagi karta horumarinta kansarka hepatocellular (HCC) ama aasaasiga ah. kansarka beerka . Daahfurkan taariikhiga ah wuxuu albaabka u furayaa daawaynta waxtarka leh ee kansarka beerka iyo hoos u dhaca waxyeelada.
SALL4 is a protein associated with tumor growth and has been used as a prognostic marker and drug target for HCC, lung cancer and leukemia. It is usually present in a growing fetus, but is inactive in adult tissues. In some cancers, such as HCC, SALL4 is reactivated, leading to buro koritaanka.
Molekuyuleyaasha daroogada ee ku shaqeeya borotiinka, sida SALL4-NuRD, waxay badanaa u baahan yihiin borotiinka la bartilmaameedsanayo inuu haysto “jeeb” yar oo qaab-dhismeedka 3-D ah, halkaasoo molikuyuullada daroogadu ka jiri karto oo shaqeyn karto. Baadhitaankii hore, waxaa lagu ogaaday in borotiinka SALL4 uu la falgalo protein kale NuRD, sameynta iskaashi muhiim u ah horumarinta kansarka sida HCC. SALL4 oo ay soo diyaariyeen kooxdan cilmi baaristu ma aysan eegin 'jeebado', laakiin waxay qaabeeyeen biomolecules xannibaysa isdhexgalka SALL4 iyo NuRD. Daraasado ayaa lagu ogaaday in ka hortagga isdhexgalkaan ay sababi karto dhimashada unugyada burooyinka isla markaana yareyso dhaqdhaqaaqa unugyada burooyinka.
FFW can effectively block protein-protein interactions, and does not require “pockets” to take effect. The research team also found that when combined with sorafenib, FFW can reduce the growth of sorafenib-resistant HCC. Although most Daaweynta la beegsaday are small-molecule drugs, well-designed peptide drugs (such as FFW) tend to have higher selectivity than large-molecule surfaces and are less toxic than small molecules.
Baaraha reer Singapore Dr. Liu Bee Hui wuxuu yiri: Iyadoo lagu saleynayo macluumaadka aan ka helnay qaab dhismeedka iyo muujinta hiddo-wadaha caalamiga ah, waxaan sii wadeynaa inaan daraasad ku sameyno peptide-kaan iyo peptides-ka kale ee leh qaababka la midka ah si aan ugu dambeyntii uga dhigno iyaga daawooyinka heerka bukaan socodka oo aan ukeenno bukaanada waxtarka.
