Heerka badbaadada kansarka ganaca waa mid aad u hooseeya. 40kii sano ee la soo dhaafay, heerka badbaadadu si weyn isumay bedelin. Helitaanka daaweyn wax ku ool ah ayaa caqabad degdeg ah u ah cilmi-baarayaasha. Sannado badan, tamoxifen ayaa loo isticmaalay in lagu daweeyo kansarka naasaha sababtoo ah waxay joojisaa estrogen si ay u kiciso korriinka burada naaska. Dhawaan, daraasado ayaa muujiyay in tamoxifen laga yaabo in loo isticmaalo daawaynta kansarka ganaca. Kooxda cilmi-baaristu waxay caddeeyeen in tamoxifen ay gacan ka geysan karto beddelka jawiga jireed ee koritaanka burada jiirka, nidaaminta horumarinta unugyada nabarrada, caabuqa iyo jawaabta difaaca. Natiijooyinka cilmi-baarista waxaa lagu daabacay "Warbixinta EMBO".
Pancreatic cancer, like most solid tumors, is surrounded by a large amount of connective tissue. The stiff scar-like tissues are like scaffolding around tumors. They block the delivery of drugs by preventing chemotherapy drugs from reaching the tumor. They also regulate the growth and spread of tumors. Samaynta unugyada isku xidha ee burooyinka ganaca (pancreatic buro) waxaa wata unugyada xididdada ganaca (PSCs), kuwaas oo lagu xoojiyo adeegsiga xoogga jirka iyo dib u habeynta qaab dhismeedka unugyada.
Markii cilmi-baarayaashu ay daraasad ku sameeyeen qaabka burada ganaca ee jiirka, waxay ogaadeen isdhexgalka ka dhexeeya unugyada ku wareegsan burada ganaca, waxayna sidoo kale daraasad ku sameeyeen sida tamoxifen u beddesho jawiga jireed ee ku wareegsan burada ganaca. Tamoxifen waxa ay awood u leedahay in ay joojiso unugyada isku xidhan ee ku xeeran burooyinka PSC sclerosis kana ilaaliso in deegaanka ku hareeraysan uu noqdo mid adag. Tamoxifen ayaa nidaamisa jawaabta difaaca waxayna joojin kartaa duulaanka iyo faafitaanka unugyada kansarka. Waxaa intaa dheer, unugyada burada ganaca waxay la kulmaan ogsijiin aad u yar, taas oo abuureysa hab ka hortag ah: marka heerka oksijiinta hoos u dhacdo, unuggu wuxuu sii daayaa molecule loo yaqaan 'hypoxia inducible factor' (HIF), kaas oo caawiya unugyada kansarka inay badbaadiyaan xaaladaha. Laakiin tamoxifen waxay joojin kartaa wax soo saarka HIF, taasoo ka dhigaysa unugyada kansarka inay u nugul yihiin heerarka ogsijiinta hooseeya waxayna u badan tahay inay dhintaan. Laakiin shaqadan hadda waxaa lagu fuliyaa dhaqanka unugyada iyo moodooyinka jiirka, sidaa darteed cilmi baaris dheeraad ah ayaa loo baahan yahay ka hor inta aan lagu dabaqin bukaannada aadanaha.
