Chii chinonzi MRD mukurapa cancer?
Measurable Residual Disease, kana MRD, izita remasero mashoma egomarara anogara mumuviri mushure mekurapa kana panguva yekurapwa. Flow cytometry, polymerase chain reaction (PCR), kana chizvarwa chinotevera kutevedzana inzira dzakasimba dzinogona kuwana aya maseru egomarara kunyangwe nzira dzekuongorora dzakajairwa, senge yekufungidzira scans, isingagone.
Kuongorora MRD kwakakosha pakusarudza nzira yekurapa mhando dzakasiyana dzegomarara reropa, senge acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic myeloid leukemia (CML), lymphomas, uye multiple myeloma. Zvinobatsira kuona kuti zvingangoita sei kuti mumwe munhu adzoke uye anogona kushandiswa kushandura zvirongwa zvekurapa sezvinodiwa.
Kana munhu aine gomarara, kuongororwa kweMRD kunoshandiswa kuona kuti kurapa kuri kushanda zvakanaka sei uye kubatsira kuronga mamwe marapirwo. Semuenzaniso, kana MRD yawanikwa mushure mekurapa kwekutanga, zvinogona kureva kuti kenza haisi kupindura zvakanaka kurapwa kwazvino uye shanduko dzinoda kuitwa. Kana, kune rumwe rutivi, MRD ikarega kuwanikwa mushure mekurapwa, zvinoreva kuti gomarara harichakura uye kuti kurapwa kuri kushanda.
Kupfupisa, MRD ipfungwa yakakosha mukurapwa kwegomarara nekuti inobatsira kuona kuti kurapwa kuri kuita sei uye kunobatsira kuronga marapirwo anotevera. Izvo zvinodiwa kuti utarise kukura kwevanhu vane marudzi akasiyana e gomarara reropa uye inogona kushandiswa kufungidzira kuti ingangoita sei kuti gomarara ridzoke.
Unogona kuda kuverenga: CAR T-Cell kurapa muChina
MRD inoonekwa sei muvarwere vegomarara?
Flow cytometry, polymerase chain reaction (PCR), kana inotevera-chizvarwa kutevedzana inzira dzakanyanya kushandiswa kutsvaga. Measurable Residual Disease (MRD) muvarwere vegomarara. Nzira dzechinyakare dzekuongorora gomarara dzinogona kupotsa nhamba shoma yemaseru egomarara anogona kuwanikwa nenzira idzi. Kuongororwa kweMRD kwakakosha kwazvo kuti utarise kuti kurapwa kwegomarara kuri kushanda sei uye kuronga marapirwo matsva.
Mumamota akasimba, kuzivikanwa kweMRD kunodiwa kuti uwane varwere vachiri nemaronda mushure mekuvhiyiwa. Chikamu che10 kusvika ku15 muzana chevarwere ava chinoda kutariswa zvakanyanya. Zvakakosha kuramba wakatarisa MRD mune vanhu vane gomarara reropa senge ALL, AML, CML, lymphomas, uye multiple myeloma kuitira kuti vanachiremba vaite sarudzo pamusoro pekurapa uye kufungidzira kuti murwere achaita sei.
Kazhinji, kutsvaga MRD muvarwere vegomarara kunoreva kushandisa nzira dzemazuva ano uye dzakasimba kutsvaga maseru egomarara anogona kusawanikwa nenzira dzechikuru. Kutevera uku kwakakosha pakuona kuti kurapa kuri kuita sei uye kuti ndeapi mamwe matanho ekurapa anofanirwa kutorwa.
Ndedzipi nzira dzakajairika dzinoshandiswa kuona MRD mune varwere vegomarara?
Dzimwe nzira dzakajairika dzekuwana Measurable Residual Disease (MRD) muvarwere vegomarara vari:
1. Kuyerera Cytometry: Iyi nzira inotarisa maitiro emaseru mumuenzaniso kutsvaga masero asina kujairika anogona kureva kuti MRD iripo.
2. Polymerase Chain Reaction (PCR): PCR inzira yemamorekuru inoshandiswa kutsvaga nekukopa chaiwo maDNA mapatani, ayo anoita kuti masayendisiti awane mashoma emasero egomarara mumuenzaniso.
3. Next-Generation Sequencing (NGS): NGS chishandiso chepamusoro-chekutevedzana chinogona kuwana shanduko yemajini yakabatana negomarara. Izvi zvinobatsira kuwana MRD nekunzwa kwakanyanya uye kujeka.
Nzira idzi dzakakosha zvikuru pakuchengeta ziso kune varwere vegomarara panguva uye mushure mekurapwa. Vanobatsira kuona kuti kurapwa kwacho kwakashanda sei, kufungidzira zvaizoitika, uye kuronga mamwe marapiro.
Unogona kuda kuverenga: CAR T-Cell kurapwa mutengo muChina
Chii chakakoshera MRD muCAR T Cell kurapwa?
Measurable Residual Disease (MRD) chikamu chakakosha che CAR T cell kurapa nekuti inobatsira vanachiremba kuona kuti kurapwa kuchashanda sei uye kuti ndezvipi mhedzisiro yekutarisira. Zvidzidzo zvakaratidza kuti kubvisa MRD mushure CAR T-cell kurapa inogona kuwedzera mukana wehupenyu, kunyanya muvanhu vane MRD mhinduro yanga isina kunaka sezvaingadai yakaita. Vatsvaguri vari kutarisa zvakare muMRD bvunzo senzira yekufanotaura kudzoka kwekutanga uye kuona kuti kurapwa kuri kushanda sei mushure. CAR T-cell kurapa.
Kune acute lymphoblastic leukemia (ALL), MRD yave mucherechedzo wakakosha wekufanotaura mhedzisiro yetsvagiridzo uye kuona kuti ndiani ari panjodzi, kunyanya kana zvasvika pakurapwa kweCAR T-cell. Kuongororwa kwakanaka kweMRD kusati kwaiswa kwakabatanidzwa kune zviri nani mhedzisiro yekiriniki muCAR-T kurapwa inoteverwa nehaploidentical hematopoietic stem cell transplantation yekudzokazve kana refractory acute lymphoblastic leukemia. Izvi zvinoratidza kukosha kwekuongorora MRD pakubudirira kwekurapa.
Pakazere, MRD ongororo chikamu chakakosha che CAR T cell kurapa nekuti inobatsira vanachiremba kuronda maitiro ekurapa, kufanotaura kudzokazve, uye kugadzirisa zvirongwa zvekurapa kuti vawane mhedzisiro yemurwere wega wega.
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MRD kuve isina kunaka kwakakosha here pamberi peCAR T Cell kurapwa?
Kubvisa MRD kwakakosha pamberi peCAR T cell therapy nekuti yakaratidzwa kuvandudza mhedzisiro yevarwere uye huwandu hwekupona. Zvidzidzo zvinoratidza kuti kurapwa kweCAR-T kunogona kubudirira kubvisa MRD uye kuwedzera kupona muvanhu vane mhinduro yeMRD isina kunaka sezvaingava. Zvakare, kuve neiyo MRD bvunzo isina kunaka isati yaiswa kwave kwakabatanidzwa kune zviri nani mhedzisiro yekiriniki muCAR-T kurapwa kweacute lymphoblastic leukemia iyo yadzoka kana kumira kupindura kurapwa. Zvakare, kana MRD ikagara kana kudzoka mushure mekurapwa, inogona kubatsira vanachiremba kufungidzira apo B-cell acute lymphoblastic leukemia varwere vachaita imwezve. Munyaya ye myeloma, kuyerwa kwekutanga kweMRD mamiriro emapfupa emapfupa chiratidzo chakanaka chekupona muCAR-T therapy. Saka, kuwana negative kune MRD pamberi CAR T cell kurapa chikamu chikuru chekuita kuti kurapwa kushande zviri nani nekuvandudza mhedzisiro yevarwere.
