Zvinoenderana neakawanda-center kiriniki kuyedza inotungamirwa nevaongorori paStanford University Chikoro cheMishonga, mhando nyowani yekudzivirira muviri inoita kunge yakachengeteka kuvarwere vane gomarara reropa inonzi non-Hodgkin's lymphoma.
The therapy combines experimental antibodies developed by researchers at Stanford University and commercially available anti-cancer antibodies to rituximab. It referred Hu5F9-G4 experimental protein antibody blockade of CD47 , of CD47 suppressed immune attack against cancer cells. The combination of two antibodies is used to treat people with two types of kwete-Hodgkin's lymphoma: diffuse large B- cell lymphoma and follicular lymphoma.
Muna 2010, vaongorori vakatungamirwa naIrving Weissman, MD, director weStanford Stem Cell Biology uye Regenerative Medicine Institute, vakaratidza kuti angangoita ese maseru egomarara akafukidzwa neprotein inonzi CD47, iyo inogona kutamba "usandidye" Chiratidzo kune macrophages.
Weissman nevamwe vaaishanda navo vakazogadzira antibody inonzi Hu5F9-G4 inovhara mapuroteni eCD47 uye inokurudzira macrophages kuvhara maseru egomarara. Rituximab inonzi antibody yakaratidzwa kuwedzera iyo yakanaka "ndidye ini" chiratidzo. Iko kusanganiswa kwe rituximab neHu5F-G4 kwakamboratidzwa kuve kunoshanda kurwisa gomarara remunhu mumhando dzemhuka, asi iyi ndiyo yekutanga kuburitswa mhedzisiro yekiriniki miedzo yekurapa muvanhu.
Pakati pevarwere makumi maviri nevaviri vaitora muyedzo, varwere gumi nemumwe vaive vaderedza kenza yekiriniki, uye varwere vasere vakabvisa zviratidzo zvese zvegomarara. Vamwe varwere vatatu mukutongwa havana kupindura kurapwa uye vakafa nekuda kwekuwedzera kwechirwere. Vatsvakurudzi vakaona kuti vatori vechikamu vaive nemhedzisiro diki.
Dr. Saul A. Rosenberg , a lymphoma professor , said that such a potential new immunotherapy is very exciting. This is the first time that an antibody that can activate macrophages to fight cancer is used, and it seems to be safe for use in humans.
https://medicalxpress.com/news/2018-10-anti-cd47-cancer-therapy-safe-small.html
