Chidzidzo chitsva kubva kuMcMaster University kuCanada chakataura kuti yakawana nzira nyowani yekurapa acute myeloid leukemia. Nekukurudzira kugadzirwa kwemasero emafuta mumwongo wepfupa uye kugadzirisa hutachiona hwehutachiona, hunogona kuvharidzira masero eukemia uye kukurudzira kugadzirwa kwesero reropa. Uyu mutsauko ndeweIyo isina kunanga kurapwa zano yeazvino chiyero kurapwa inoita kunge ine zvakanakira, kwete kunze chete asiwo mukati. (Nat Cell Biol. 2017; 19: 1336-1347. Doi: 10.1038 / ncb3625.)
Acute myeloid leukemia (AML) inoratidzirwa nechizvarwa chemasero eheukemia akasarudzika. Varwere vanotambura nehutachiona hwakanyanya uye kupererwa neropa nekuda kwekukwana kugadzirwa kwemasero matsvuku eropa. Kwakajairika kurapwa kwakanangana nekuuraya maseru eecukemia aine firepower, achiregeredza kugadzirwa kwemasero matsvuku eropa.
Zvichibva pakucherechedzwa kwevarwere veleukemia, vaongorori vakaunganidza huwandu hwakawanda hwemapfupa kubva kune varwere veleukemia kuti vaongorore, vachienzanisa uye vakafananidza maseru ane hutano mumongo wemapfupa nemaseru eukemia, uye vakawana izvi zvakakonzerwa nemaseru emafuta. Kubudikidza ne in vitro cell tsika uye kuisirwa bundu modhi kuyedza, ivo vaongorori vakawana kuti yakaoma myeloid leukemia maseru akanyatso kuparadza iyo microenvelo yemafuta maseru mumongo wemapfupa, zvichikonzera kudzikama kusadzikama kwemasero ehematopoietic maseru uye maseru eanogadzira uye kudzora kugadzirwa kweropa rakajairika. masero mumapfupa emapfupa.
Chidzidzo chakaratidza kekutanga hukama uhwu pakati pechizvarwa cheadipocyte mumapfupa emapfupa uye zvakajairika mwongo wemapfupa erythrocytes. Izvi hazvisi chete nekuda kwehematopoietic microenvelo yemongo wemapfupa, ndiko kuti, iyo niche yakazara, asiwo basa readipocytes mukusiyanisa maitiro. Iyo inogumira mhedzisiro yemaseru eukemia. Uku kuwanikwa kunopa mitsva yekurapa mazano e myeloid leukemia uye inotarisirwa kugadzirisa zviratidzo zvekukundikana kune varwere vane myeloid leukemia.
Ichitsigirwa nemushonga unokurudzira kugadzirwa kwemafuta maseru, maseru emafuta ari mumwongo wemapfupa akabudirira kusvina maseru eecemia, zvichiita mukana wekugadzirwa kwesero reropa uye kujekesa portal. In vitro kuyedza, PPARγ inhibitors inogona kukurudzira chizvarwa chemapfupa emongo adipocytes. Nekushandura iyo yemongo boneen microenvironment, inopa hutano kune hutano kugadzirwa kwemasero eropa uye panguva imwechete inodzivisa kuumbwa kwemaseru eukemia, ayo anogona kupa nzira nyowani yekurapa zvisina kunangana kweacute myeloid leukemia. Iyi nzira isina kunangana yekurapa inofanirwa kunge ichinyanya kuvimbisa kupfuura marapirwo akajairwa, ayo asina kuita fambiro mberi yakawanda mumakumi mashoma apfuura.
Vatsvakurudzi vakaratidza kuti chinangwa chekurapa kwagara chiripo kuuraya masero ebundu, kushandura nzira yekufunga, uye kutora nzira dzakasiyana dzekushandura nharaunda yekupona kwemasero egomarara kuti uwane kurapa. Ipo ichidzvanyirira cancer maseru, inosimbisa maseru ane hutano kuitira kuti vagone kumutsiridza munzvimbo nyowani inokonzerwa nemishonga.
