Yakananga masaini masaini anoburitswa nepancreatic cancer maseru akatemerwa. Pancreatic cancer inowanzo onekwa mushure mekunge chirwere ichi chapararira, uye chemotherapy kazhinji haina mhedzisiro inonotsa kukura kwegomarara. Kunyangwe nekurapwa, varwere vazhinji vanogona kungorarama kweinenge mwedzi mitanhatu mushure mekuonekwa vaine pancreatic cancer.
Mukenza yepancreatic, fibroblasts yakawandisa, inotarisisa kweanoda kusvika makumi mapfumbamwe muzana muzana yemota yakakura. Iyi matrix inodzivirira anticancer madhiragi kupinda mukati mechinangwa. Uye zvakare, masero e stromal anounza zvinhu zvinobatsira mukukura kwemarara. Vanotsvagisa murabhoritari yaPurofesa David Tuveson kuCold Spring Harbour Laboratory (CSHL) vanotenda kuti marudzi akasiyana ekurapa anogona kuve nani. Chikamu chechinetso ndechekuti maseru ekenza ari mupancreas anochengetedzwa nematrix machena akaatenderedza. Iyo stroma musanganiswa wezvinhu zvekunze maseru uye zvisina maseru gomarara anonzi stroma. Mamota ese akasimba ane stroma. Kukunda zvinodzivirira matrix kunonetsa, asi sezvakataurwa mumagazini Cancer Discovery muna Gumiguru 26, 2018, iyo nyowani yekuziva kubva kuchikwata cheTuveson inonongedzera kuchirongwa chinovimbisa. Izvo zvitsva zvakawanikwa zvinoratidza kuti mishonga inotarisa nzira chaiyo yemaseru kwete chete inodzivirira maseru-anotsigira maseru mumatrix, anogona kuendeswa kunorwa nekenza.
Chinokosha kumatrix ndeye fibroblasts, iyo inogona kuburitsa inosangana matishu ematrikisi, uye inogona zvakare kuburitsa zvinhu zvinokurudzira kukura kwemasero ekenza uye kudzivirira immune system kubva pakurwisa maseru ekenza. Gore rakapera, timu yaTuvveson yakaona kuti pancreatic tumor stroma ine angangoita maviri marudzi e fibroblasts. Rumwe rudzi runoratidza maficha anozivikanwa kutsigira bundu kukura, uye imwe mhando inoratidza zvinopesana. Nhau dzakanaka ndedzekuti kuzivikanwa kwefibroblasts hakuna kugadziriswa, uye bundu-rinokurudzira fibroblast rinogona kuve bundu rinodzora zvinhu. Giulia Biffi, mutsvagiri wezvekurapa murabhoritari yeTuvveson, akatsanangura, "Aya maseru anogona kushandurana kuita mamwe, zvichienderana nezviratidzo zvavanowana kubva kuma microenvelo nekenza maseru. Mune dzidziso, iwe unogona kushandura mamota-anosimudzira maseru kuita mamota anodzvinyirira, Hazvisi izvo chete zvinodzora mamota-anosimudzira maseru. ”Vakaona kuti IL-1 inotyaira fibroblast ane bundu-rinokurudzira zvivakwa. Vakaona zvakare kuti imwe mamorekuru, TGF-β, inovhara sei chiratidzo ichi uye inochengeta fibroblast mune inogona kurwisa kenza nyika. Biffi akati varwere vanogona kubatsirwa zvakanyanya kubva mukubatanidzwa kwekurapa kwakanangana nemaseru ekenza uye chikamu chemhepo inotsigira kukura kwavo.
https://www.medindia.net/news/pancreatic-cancer-fresh-insights-183360-1.htm
