Kana uri kuverenga izvi, iwe kana kuti mumwe wevadiwa vako ari parwendo rwusina anomboronga kutora-nzira yekutarisana negomarara.
Isu tinonzwisisa kuti mugwagwa uyu uzere nekusavimbika, kutya, uye nguva apo inonzwa sekunge nyika yapinduka. Asi pane mashoko akanaka kwauri, anogona kupedza kushushikana kwako!
Ngatitaure nezve chimwe chinhu chinogona kuunza mwaranzi wegoridhe wetariro parwendo rwako - immunotherapy.
Kunopfuura kungova mushonga; imwaranzi yetariro uye chiyeuchidzo chinogara chiripo chekuti hausi wega, sainzi iri kurwisana newe.
Mune ino blog, tichakurukura basa rakakosha re immunotherapy mukurapa lymphoma, iyo iri kupa varwere vekenza tariro itsva.
Tichakuratidza kuti sei mota T cell therapy kurapwa muIndia ndiyo nzira yakangwara uye inoshanda kupfuura mamwe maitiro ekurapa. Saka, namatirai, uye ngationei zvinoshamisa mabhenefiti e immunotherapy lymphoma pamwe chete!
Chii chinonzi Lymphoma?
Lymphoma imhando yegomarara rinotanga mune yedu lymphatic system, inova chikamu chakakosha che immune system yedu.
Imhando yemasero machena eropa anoumbwa mumwongo. Aya ma lymphocyte anotenderera mumiviri yedu kuburikidza neropa uye lymphatic systems.
Iyo lymphatic system, ine zvinhu zvakakosha zvakadai semalymph nodes, inoshanda semudziviriri kuburikidza nekusefa lymph fluid kubvisa kunze kwenyika.
Mhando dzakasiyana-siyana dze lymphocytes, kusanganisira B masero, T masero, uye muurayi wechisikigo (NK) masero, anokura mukati me lymph nodes kurwisa mabhakitiriya uye vaparadzi vari mu lymph fluid.
Lymphomas inoitika apo lymphocyte ine hutano inoshanduka kuita masero ane kenza. Izvi zvinokamura lymphoma mumarudzi matatu: B cell lymphomas (yakanyanya kuwanda), T cell lymphomas, uye NK cell lymphomas (zvishoma zvishoma asi zvinogoneka).
Kunyangwe kubata nelymphoma kune hunyengeri, nzira dzemazuvano senge mota t immunotherapy yelymphoma dziri kutipa tariro uye nekupa simba immune system yedu kurwisa yakasimba kunyangwe matambudziko aanounza.
Mhando dzeLymphoma
Lymphoma inonyanya kubata vana nevakuru vechidiki uye yakakamurwa kuva marudzi maviri -
Hodgkin Lymphoma (HL)
Rudzi urwu rwe lymphoma runoratidzwa nekuvapo kwesero rakati risiri iro rinonzi Reed-Sternberg cell.
Hodgkin's lymphoma kazhinji inotanga mumalymph nodes uye inogona kupararira kune dzimwe nhengo dzemuviri. Hazvina kunyanya kuwanda pane isiri-Hodgkin lymphoma.
Non-Hodgkin Lymphoma (NHL)
Iri iboka rinowanzozivikanwa uye rakasiyana-siyana re lymphomas rinosanganisira ma subtypes akasiyana. Non-Hodgkin lymphomas inogona kubuda kubva kumarudzi akawanda e-lymphocytes uye inogona kukanganisa lymph nodes, spleen, bone marrow, nedzimwe nhengo.
Sei CAR T YeLymphoma Iri Kunyorazve Mitemo yeCancer Care?
India ichangobva kuunza nzira yayo ine simba uye inoshanda yekubatsira vanhu vanotambura nelymphoma. Iyi itsva immunotherapy kurapwa kwe lymphoma yakafanana nekupa immune system yako kusimudzira kune simba.
CAR T inomirira "Chimeric Antigen Receptor T-cell," izvo zvingaite sekunge zvakaoma, asi ndiyo nzira yakanakisa yekuchajisa maseru emuviri wedu.
Vanachiremba vanotora mamwe emasero edu ekudzivirira muviri, voashandura murabhoritari kuti vaone uye vatarise masero e-lymphoma, vobva vaadzosera mumiviri yedu kuti tione uye kubvisa masero egomarara.
Zvinoenderana nezvidzidzo, CAR T-cell therapy ine yakakwira budiriro mwero, ine chikamu chikuru chevarwere vanopindura zvakanaka.
Somuenzaniso, in kliniki miedzo nokuda kwemhando dzakasiyana dze lymphomas, mhinduro dzehuwandu dzakapfuura 80%, zvichiratidza simba guru pachirwere.
Kurapa uku kunonyanya kubatsira kune varwere vasina kupindura zvakanaka kune zvakajairwa marapirwo. The mutengo wemotokari t cell kurapwa muIndia inenge $ 57,000.
Zvakadaro, mumazuva anotevera makambani akaita seImmuneel neCellogen achaparura kurapa kwavo kutsva kweCAR-T uko kuchabva pamadhora makumi matatu ezviuru kusvika pamadhora makumi mana.
Sei Immunotherapy YeLymphoma Cancer Yakasiyana NeKurapwa Kwemazuva Ano?
Zvakanaka, ngatizviparadze! Immunotherapy kurapwa kweHodgkin's lymphoma uye Non-Hodgkin lymphoma ine budiriro yakakura zvichienzaniswa neyakajairwa marapirwo.
Chemotherapy-
Mushonga une simba unoshandisa intravenous kana mishonga yekunwa kuti inonangana nekuparadza kenza masero mumuviri wose.
Kunyange zvazvo chemotherapy inoshanda pakurwisa lymphoma, inogonawo kuva nemigumisiro yakaipa pamasero ane utano, zvichiita kuti pave nemigumisiro yakakomba.
Radiation therapy
Kurapa uku kunowanzo kupetwa nechemotherapy uye kunoshandisa yakakwirira-simba X-rays kunanga zvakananga lymphoma masero akaungana mumalymph nodes.
Stem Cell Inoshandura
Stem cell transplants, inowanzonzi bone marrow transplants, inogona kudikanwa sezvo chemotherapy neradiation therapy inogona kukuvadza hutano. masero eropa pamwe negomarara masero. Kurapa uku kunotsiva masero eropa ane hutano kuti atsigire kupora.
Photopheresis
Iyo imhando yephotoimmunotherapy inoshandisa mwenje kumisa immune system mukurwisa mamwe marudzi e lymphoma anogona kukonzerwa ne stem cell transplantation.
Phototherapy
Phototherapy inoratidzika seyo nzira inovimbisa yekurapa kune yekutanga-nhanho yekucheka T cell lymphoma. Inoshandisa ultraviolet (UV) chiedza kunanga uye kuparadza masero egomarara reganda.
Surgery
Kunyange zvazvo kuvhiyiwa kunowanzoshandiswa kuongorora lymphoma, kune mamwe mamiriro ezvinhu umo tumarara kupedzwa kuburikidza nekuvhiya resection kunoonekwa kwakakodzera.
Kunyatsotarisa paImmunotherapy's Side Effects
Dzidza nezve mhedzisiro ye immunotherapy mukurapa lymphoma. Mhedzisiro yacho inosiyana kubva kumunhu kuenda kumunhu, zvichienderana nekuti ndeye immunotherapy yeHodgkin's lymphoma, immunotherapy yefollicular lymphoma, kana immunotherapy yehombe b cell lymphoma. Nekudaro, mamwe eakajairwa immunotherapy ye lymphoma mhedzisiro ndeaya anotevera -
Kuneta
Skin Reactions
Flu-Kufanana Zviratidzo
Nausea uye Kurutsa
Dhairrhea kana Kuvimbiswa
Kurasikirwa neHupengo
Ropa Clots
Dzungu Kana Kuvhiringika
Headaches
Low Blood Cell Count
Kunzwisisa Mhando dzeImmunotherapy Treatment Option
Basa reImmunotherapy muLymphoma Kurapa kwakakosha sezvo idzi nzira dzekuvandudza dziri kugadzirisa kurapwa kwegomarara. Ngationei kuti mishonga yakakosha iyi, kubva kune masoja ekudzivirira chirwere ichi kuenda kumajekiseni, iri kushandura sei mutambo mukurwisa gomarara.
Monoclonal Antibodies
Monoclonal antibodies ndiwo mamorekuru akagadzirwa murabhoritari anodzokorora kugona kwe immune system kurwisa maseru anokuvadza. Anoshanda nekubatanidza kune chaiwo mapuroteni ari pamusoro pemasero egomarara.
Aya masoja ekudzivirira chirwere anogona kudzivirira maseru egomarara kuti asakura zvisingadzoreki, abatsire immune system kuona maseru ane gomarara kuti abvise, kana kutanga maitiro anoita kuti masero ane gomarara azviparadze ega. Iyi inoshanda chaizvo B-cell lymphoma immunotherapy.
Immune Checkpoint Inhibitors
Iyi ndiyo inonyanya kushanda immunotherapy ye t cell lymphoma. Immune checkpoint inhibitors inovhara mamwe mapuroteni pamasero emuviri kana maseru ekenza, zvichibvumira immune system kuti ione uye kurwisa cancer maseru zvakanyanya.
Mukati megadziriro inodzivirira zvirwere, masero akajairwa ane mapuroteni ekuongorora anoita zvisungo nemapuroteni ari muT masero, zvichiratidza kuti masero eT arege kurwisa.
Masero egomarara, kune rumwe rutivi, anogona kunyengedza gadziriro yomuviri yokuzvidzivirira pazvirwere kuti iafungidzire masero ane utano. Inhibitors inopindira nekuvhiringidza aya mapuroteni pairings, kuve nechokwadi chokuti masero eT anonyatsoziva uye anotanga kurwisa masero e lymphoma.
Serura Immunotherapy
Cellular immunotherapy inzira yekushandura masero emuviri emuviri wemurwere (kazhinji T masero) kuitira kuti avandudze kugona kwavo kuona nekubvisa maseru egomarara.
CAR T-cell therapy (Chimeric Antigen Receptor T-cell) muenzaniso unozivikanwa we cellular immunotherapy. Nenzira iyi, masero eT anogadzirwa genetically engineered kuratidza receptor inoziva maseru egomarara, ichigadzira mhinduro ine simba uye yakasarudzika yekurwisa cancer.
Therapeutic Cancer Vaccines
kuchirapa majekiseni egomarara kukurudzira immune system kuziva uye kurwisa cancer maseru. Kusiyana nemajekiseni akajairwa, anoedza kudzivirira zvirwere, majekiseni aya anovavarira kurapa mamota aripo.
Aya majekiseni anogona kugadzirwa kuti atarise mapuroteni chaiwo mumaseru egomarara uye kukurudzira mhinduro yekuzvidzivirira kubva kugomarara.
Hupenyu Hwechokwadi Hwakabatwa neImmunotherapy Kurapa
Sangana naShawn, mukomana ane makore makumi maviri nemapfumbamwe wekuHong Kong ane rwendo rwegomarara rwakatanga aine zviratidzo zvefivha, kuneta, uye kucheneruka kweganda munaKurume 29.
Shawn akatanga kurapwa muchipatara chePrince of Wales Hospital mushure mekubatwa nechirwere ichi acute B-lymphocytic leukemia. Mushure mekubudirira kurapa chemotherapy uye neradiation kurapwa, akaratidzika kunge akagwinya uye akanaka muna Kubvumbi.
Nekudaro, kuongororwa kwemwongo wemapfupa musi waKubvumbi 19, 2018, kwakawana kuvepo kwegumi muzana yegonorrhea yevadiki. Vakatarisana nedambudziko iri, nyanzvi dzeHong Kong dzakakurudzira kuti chemotherapy yechinyakare inogona kunge isina kukwana uye vakakurudzira kurapwa kweCAR-T senzira inovimbisa.
Ipapo ndipo Shawn akasarudza kutora chikamu muchidzidzo chekiriniki, achiitwa genetic modified yeT-cells yake kugadzira "chimeric antigen receptor (CAR) T-seli." Aya masero akasiyana anogadzirwa kuti atarise maseru egomarara.
Musi wa6 Chivabvu, Shawn akarapwazve chemotherapy. Musi waChivabvu 11, akagamuchira infusion yeCD19 CAR T masero. Mishumo yakazara yakaratidza kusakanganiswa muCSF kuwirirana, kuyerera kwecytometry, bone marrow cell morphology, kuongororwa kweDNA, kana chirevo cheCAR-T mushure memavhiki mana ekunyatsotarisisa uye nedivi-effect management.
Shawn akange awana kupora zvachose, zvichiratidza kubudirira kukuru muhondo yake yekurwisa cancer. Pashure pokupora kunoshamisa kudaro, Shawn ari kugadzirira chikamu chinotevera cherwendo rwake—kuzoiswa bhonzo uye kuiswa ropa paanodzokera kuHong Kong.
Ngano yake yekukurudzira inosimbisa shanduko yeBasa reImmunotherapy muLymphoma Kurapa uye mukukunda chirwere chinouraya sekenza.
Ngatikunde Gomarara Pamwe Chete!
Patinopeta tsvakiridzo yedu munyika yeimmunotherapy yekurapa lymphoma, ngatibatirei pane chimwe chinhu chakakosha - tariro.
Funga nezve immunotherapy kana CAR-T Cell Therapy semhare pane yako timu inorwisa cancer, ichipa nzira nyowani kune idzo nguva dzakaoma.
Kubudirira kwega kwega nyaya, nhanho imwe neimwe yesainzi, yakafanana nechiedza chakajeka murwendo rwekurwisa kenza. Kana iwe kana mumwe munhu waunoziva ari parwendo urwu, rangarira kuti wakasimba kupfuura zvaunofunga, uye nhanho yega yega yaunotora kuenda kunorapwa uku kukunda.
Saka ngatitarisei pamwe chete sezvo tariro chiricho chombo chedu chine simba mukurwisa gomarara. Hausi wega, uye nzira iri kumberi yakazadzwa nemikana yemangwana akajeka, ane hutano. Svika kwatiri nhasi kuti uchinje rwendo urwu rwakaoma kuti ruve mangwana akajeka!
