Sarcoma, iyo inowanikwa muvechidiki uye iri bundu rakaipa rinobva mumesenchymal tishu (inosanganisira inosanganisa nyama uye mhasuru). Sarcomas ane huipi hwakanyanya uye anokura nekukurumidza! Kazhinji sarcomas inosanganisira osteosarcoma, leiomyosarcoma, lymphosarcoma, uye synovial sarcoma. Leiomyoma, lymphosarcoma, uye synovial sarcoma inogona kukura metastases eropa panguva yekutanga.
Nzira yakasarudzwa ye sarcoma kuvhiyiwa. Kuti vatsvage kurapwa, vanachiremba vemudzimba vanowanzoda kuti varwere vadimburwe makumbo nemaoko. Zvakadaro, parizvino zvakaoma kurapa isingagadzirike kana advanced liposarcoma uye leiomyosarcoma inoitika kuseri kweperitoneum uye ine mamota makuru. Zvipatara zvemumba nekune dzimwe nyika zvinowanzochengeta mitezo yakawanda zvobva zvaita radiotherapy.
Sarcoma haina hanya nemishonga yechemotherapy! Kushanda kweradiotherapy yemunharaunda zvakare kwakashata, asi kana metastases yemapapu isinganyanyi kushanda.
Palbociclib capsule inonyanya kusarudza inhibitor ye cyclin-inotsamira kinases CDK4 uye CDK6. Ndiyo zvakare yekutanga kenza yemazamu immunotherapy inhibitor kubvumidzwa neUS FDA. Palbociclib capsules inonangwa mishonga yekurapa sarcoma.
Mashandiro anoita Palbociclib: Maseru ese anorarama ari muchikamu chemasero, uye Palbociclib inogona kudzvinyirira nzira yekuparadzanisa maseru, uye kusanganisa Palbociclib nemamwe marapirwo anorwisa gomarara senge endocrine therapy, chemotherapy, uye mamwe marapirwo anotarisirwa anogona kubata akawanda marudzi ekenza Gadzira ine simba. kurapa.
Targeted kurapwa inogona kushandisa akasiyana madhiragi uye kumwe kupindira kunyatso kuona uye kurwisa gomarara maseru pasina kukuvadza zvakajairika maseru. Dr. Peter J. O'Dwyer vakati pamusoro pe neutrophils, Palbociclib ine Maitiro emasero zvakare ari madiki, uye mushonga unogona kutadzisa kukura kwemamota mumamota. Sezvatinoona mabasa matsva eakananga CDK4 / 6, tinogona kukudziridza mubatanidzwa mutsva wezvinodhaka sevamiririri vekenza-kenza.
Zvinoenderana nemhedzisiro yekutsvagisa uye yekutanga mhedzisiro yekiriniki yekuyedzwa yakaburitswa nesainzi paYunivhesiti yePennsylvania mujenari JAMA Oncology, mhedzisiro yechikamu chechipiri chekiriniki yevarwere makumi maviri nevaviri vane sarcoma inoratidza kuti mushonga wePalbociclib unogona kuwana yepakati kufambira mberi-kusina kupona kwemakumi matanhatu nematanhatu. % yevarwere mavhiki gumi nemaviri. Palbociclib inoshanda mukurapa sarcoma uye inogona kurebesa kufambira mberi-kusina kupona kwevarwere.
