Zvinoenderana nemhedzisiro yakaziviswa pamusangano wepagore we2018 ASCO, CDK4/6 inhibitors pabociclib (Ibrance) uye cetuximab (Erbitux) yakasanganiswa kurapwa kweplatinamu-inodzivirira uye HPV-yakasununguka inodzokororwa / metastatic musoro nemutsipa Iyo yakazara mhinduro yevarwere vane squamous. cell carcinoma (HNSCC) i39%. Mune isina-randomized, 3-ruoko, chikamu II kuyedza (NCT02101034), mhedzisiro yeboka rezvidzidzo ine yepakati-yemahara yekurarama (PFS) yemwedzi 5.4, yepakati pese kupona (OS) ye9.5 mwedzi, uye a 1-gore OS Muyero i35%.
Muchidzidzo ichi, varwere makumi matatu vane HNSCC isina hukama neHPV vakafambira mberi mushure meplatinum-based therapy yekudzokazve / metastatic chirwere uye vakapinda muyedzo. Varwere vakambogamuchira cetuximab yekudzokazve uye HPV-inoenderana neoropharyngeal cancer vaive vasina kukodzera. Varwere vakagamuchira palbociclib kubva pazuva 30 kusvika zuva 1, 21 mg zuva nezuva; cetuximab, ine chiyero chekutanga che 125 mg / m 400 uye ipapo 2 mg / m 250 pavhiki kwemazuva makumi maviri nemasere kusvikira chirwere ichi chichienderera mberi kana kubvisa chidzidzo. Vatsvagiri vakaita bvunzo dzekufungidzira vasati varapwa uye mushure mega ega 2 kutenderera.
Iyo yepakati zera yevarwere yaive makore makumi matanhatu nemanomwe, uye nzvimbo dzemota dzaive dzemuromo mhango (67%), larynx (47%), uye oropharynx (27%). 13% yevarwere vane metastases yemunharaunda, 20% vane metastases ari kure, uye 27% vane zvese zviri zviviri. Gumi neshanu (53%) varwere vakagamuchira treatments 50 kurapwa.
Pakati pevarwere makumi maviri nemasere vanoongororwa, 28 (11%) vaive nemamota mhinduro, kusanganisira 39 (3%) mhinduro dzakazara uye 11 (8%) mhinduro shoma. Vane gumi nemana (29%) varwere vaive nezvirwere zvakagadzikana, 50 (3%) varwere vaive nekufambira mberi, uye 11% yakadzora mamota maronda.
Muongorori Dr. Adkins akataura kuti Palbociclib uye cetuximab vane yakasimba antitumor basa muplatinamu-inodzivirira HPV-inomirira kenza yemutsipa nemutsipa, uye biologically tarisiro yekurapa kweHPV-yakazvimirira yegomarara yemusoro nemutsipa inzira inoshanda yekurapa. . Isu tinotarisira kune zvirinani mhedzisiro yekutsvaga yekutevera.
