Muna Kurume 2024, kuburitswa kwenhau kwakataura kuti A2B530 (A2 Biotherapeutics), CAR T-cell therapy, yakapihwa Orphan Drug Designation yekurapa colorectal cancer inoratidzira carcinoembryonic antigen (CEA) uye yakarasikirwa neHLA-A * 02 kutaura muvanhu vane germline. heterozygous HLA-A*02 (+) chirwere.
Vatsvagiri vanofunga kuti autologous logic-gated cell therapy inogona kunanga bundu maseru ichidzivirira hutano. Izvi zvinodaro nekuti ine yakavakirwa-mukati yekuchengetedza switch iyo inogona kuchengetedza hutano hutano kubva mukukuvadzwa. Muchikamu che1/2 EVEREST-1 (NCT05736731) chidzidzo, pfungwa iyi ichaedzwa.
Unogona kuda kuverenga: CAR T-Cell kurapa muChina
Sarudzo yeFDA yekupa Orphan Drug Designation inosimbisa kukosha kukuru kusingakwane kwemishonga iri nani kune vanhu vane colorectal cancer,” akadaro William Go, MD, PhD, mukuru wekurapa weA2 Bio, mukuburitswa kwenhau. Iri zita rinotsigira vimbiso yedu yekushandisa yedu yekucheka-kumucheto tekinoroji chikuva kugadzira gomarara idzva kurapa kune vanhu vane gomarara rakaoma kurapa.
Iyo yakavhurika-label, chikamu 1/2 EVEREST-1 chidzidzo chiri kutarisa kuA2B530 senge ingangoita kurapwa kwemamota akasimba senge colorectal cancer, pancreatic cancer, uye. isina-diki kenza yemapapu kenza. Inotarisawo mamwe marudzi emamota akasimba anoburitsa CEA asi kwete HLA-A*02. Vanhu vave muchidzidzo cheEVEREST-1 vakatanga muchidzidzo cheBASECAMP-1 (NCT04981119), kwaiunganidzwa masero eT avo, akagadziriswa, uye akachengetwa kuti azoshandiswa gare gare.
Unogona kuda kuverenga: CAR T-Cell kurapwa kweyakawanda myeloma muChina
Chinangwa chikuru chechikamu chekutanga chekudzidza ndechekutsvaga yakachengeteka uye inoshanda zvakanyanya. Kuchengetedzeka uye kushanda nesimba kunofanirwa kuchengetedzwa sezvinangwa zvikuru zvechikamu chechipiri chekudzidza. Huwandu hwakasimba tumarara masero ayo akakurudzirwa dose anogona kuuraya achiri kuchengetedza masero ane hutano.
Colorectal cancer, rinova izwi kune ese ari maviri colon uye rectal cancer, zvinoitika apo polyps (mapoka emasero anokura pamwechete) anoumba mucolon kana rectum oshanduka kuita gomarara. Kuchembera, kuva mutema, kuve nenhoroondo yemapolyps kana gomarara mumuviri wako kana mumhuri yako, chirwere chebowel, genetics, chirwere cheshuga, kufutisa, kudya kwakajairika kwekuMadokero, uye kuputa nekunwa zvese zvinhu zvinoisa vanhu panjodzi.
Kuvhiya, radiation, kurapa kwakanangwa, uye immunotherapy ndiyo nzira dzakajairika dzekurapa cancer cancer. Zvakadaro, nzira zhinji dzemazuva ano dzegomarara iri nedzimwe dzine mamota akasimba dzinogona kuuraya varwere.
Unogona kuda kuverenga: CAR T Cell kurapwa mutengo muChina
Vatsvakurudzi vakashanda pachidzidzo ichi vanofunga kuti izvi CAR T-cell kurapa haina njodzi pane mamwe marapirwo anonangwa. Izvi zvinodaro nekuti CAR T-masero uraya bundu maseru pasina kukuvadza maseru ane hutano nekuti ane yakavakirwa-mukati yekuchengetedza switch inochengetedza hutano hutano kubva mukukuvadzwa.
