Musi waGumiguru 19, 2016, mushonga mutsva Olaratumab wakapfuudza mvumo yekukurumidza yeUS FDA uye inogona kusanganiswa ne doxorubicin kurapa mamwe marudzi easoftoma sarcoma (STS) muvakuru.
portant; izwi-kuputira: kutyora-shoko! zvakakosha; chinyorwa: hapana 0px! zvakakosha; "> Muna Chivabvu gore rino, FDA yakapa Olaratumab pamberi pekuongorora bvunzo. Olaratumab yakatanga kugadzirirwa kuvharidzira iyo PDGFRα nzira yekusaina mumamota maseru uye microenvironment. Mukupindura kune iyi nzira yekuita, Olaratumab akapasisawo FDA "yekubudirira mushonga", "Fast Track" uye "Nherera Zvinodhaka" mvumo.
portant; izwi-kuputira: kutyora-shoko! zvakakosha; chinyorwa: hapana 0px! zvakakosha; "> Olaratumab ndeye munhu-yakatorwa IgG1 monoclonal antibody ine yakakwira yakanangana nehukama hwemunhu platelet-inotorwa kukura factor receptor α (PDGFRα). Zvimwe zvidzidzo zvakaona kuti PDGFRα inowanikwa mune dzakasiyana bundu tishu Kuratidzira, uye iyo isina kujairika activation yeiyi receptor ine humwe hukama nemamota. Preclinical zvidzidzo zvinotenda kuti PDGFRα inogona kuwedzera bundu kuwedzera uye metastatic kugona.
portant; izwi-kuputira: kutyora-izwi! important; rondedzero: hapana 0px! zvakakosha; "> Olaratumab ndiyo yekutanga STS kurapwa mushonga mushure mekunge indosine neradiotherapy zvakabvumidzwa kupfuura makore makumi mana apfuura. Kune varwere ava, nzira yekurapa yainyanya kushandiswa yaive doxorubicin kana Sanganisa nemimwe mishonga.
portant; izwi-kuputira: kutyora-shoko! zvakakosha; chinyorwa: hapana 0px! zvakakosha; "> Muedzo wekiriniki wevarwere ve133 vane metastatic STS ine makumi maviri neshanu emhando dzakasiyana dzematishu akaongorora kushanda uye kuchengetedzeka kweOlaratumab. Migumisiro yekudzidza yakaratidza kuti Olaratumab yakasanganiswa ne-single-agent adriamycin treatment Kupona kwevarwere vari muboka rekurapa adriamycin kwakagadziridzwa zvakanyanya, nepakati pehupenyu hwese hwe25 vs 14.7 mwedzi; kufambira mberi-kusina kupona kwe26.5 vs 4.4 mwedzi; uye bundu regression rates ye8.2% vs 7.5%, zvichiteerana.
portant; izwi-kuputira: kutyora-shoko! zvakakosha; chinyorwa: hapana 0px! zvakakosha; ">Kurapwa kweOlaratumab kune njodzi yezviitiko zvakakomba, kusanganisira kuisirwa-zvinechekuita nekukuvara kwe "embryo-fetal". Maitiro ane chekuita nekunyudzwa anosanganisira hypotension, fivha, kutonhora, uye mapundu. Migumisiro yakajairika yekurapa ndeyekusvotwa, kuneta, uye kusarerekera Granulocytopenia, kurwadziwa kwetsandanyama, mucositis, kurasikirwa nebvudzi, kurutsa, manyoka, kurasikirwa kwechido, kurwadziwa mudumbu, neuropathy, uye musoro.
