Mhosva dze NK cell immunotherapy yekenza yechiropa yakakwira
92-makore-ekuberekwa kenza murwere ane kuregererwa kwakakwana
Makore manomwe apfuura, Mai M, avo vaiva mumakore avo okuma80, vakabatwa nehepatocellular carcinoma (yaikonzerwa nekenza munguva yakapfuura nemhaka yokuwedzerwa ropa uye kutapukirwa neutachiona hwehepatitis C). Nemhaka yokuti akanga aine utano hwakanaka panguva iyoyo, akavhiyiwa zvinobudirira.
Muna 2016, gomarara rakadzokazve, asi tichifunga kuti Amai M vanga vatochembera panguva ino, kuvhiyiwa kwainge kusisakurudzirwe.
Ms. M. was born into a medical family, and her daughter is also a doctor. She consulted on many treatments suitable for mothers other than surgery. Due to the poor location of the tumarara, radiofrequency and embolization treatments are not feasible. Among the most cutting-edge radiotherapy methods, the first is to exclude heavy ions, which are not applicable at all, and the second is proton therapy, uye simba raamai haritsungiririki. Pakupedzisira, banga reTOMO chete ndiro rinogona kunyatsoona chirwere chakaoma chaamai. Irradiation.
Doctors suggest that Ms. M should be treated conservatively at such an old age. You can try a mild systemic treatment-NK cell reinfusion to improve immunity without using the toxic and side effects of drug treatment. At the same time, combined with Tom knife radiotherapy to kill kenza masero.
Iyo yakakwira yekumisikidza nguva yeNK cell kudzoreredza mumuviri mazuva 2-3, saka Mai M vanoita NK cell kudzokedzana pakupera kwevhiki mushure memuno radiotherapy neTOMO banga. NK maseru anokwanisa kufamba neropa mumuviri wese kuzadzisa zvemuno + systemic kurapwa synergy Zvirinani kurapwa maitiro neanti-kenza mhedzisiro.
Mushure mekurapwa, ultrasound uye PET-CT kuongororwa kwakaratidza kuti chironda chemurwere chaive chakanyanya mamiriro. Ronda remunharaunda rakanyangarika, kunetsekana kwemurwere nezve metastasis hakuna kuoneka, hakuna jaundice uye ascites, uye muviri wemurwere zvishoma nezvishoma wakapora.
NK cell systemic inorwisa kenza kurapwa
NK (natural killer cell, NK) is immune cell ine simba rekurwisa cancer. Chinhu chakanyanya kusimba ndechekuti hachidi iyo antigen mharidzo yekuita uye haidi mamwe maseru edziviriro kuti adzore. Inogona kutora danho, yakananga, uye nekukurumidza kubvisa miviri yekunze (Virus mabhakitiriya anokanganisa masero, kenza maseru, maseru maseru, etc.) Local Fa-rectification.
Kunyange zvazvo vanogona kukurumidza kudzivirira uye kurwisa zvakananga bundu masero, zvinosuruvarisa, NK masero inongova chikamu chiduku chegadziriro yezvirwere zvemuviri, inotora 10% chete yemasero machena eropa. Uye chidzidzo chacho chakawana kuti mushure memakore makumi maviri nemashanu, kudzivirirwa kwevanhu kunoderera uye nhamba yemasero eNK inova shoma. Huwandu uye basa reNK masero mune bundu varwere uye varwere mushure mekuvhiyiwa bundu vakachinja kune imwe nhanho, uye havagone kuita zvinobudirira anti-cancer mhedzisiro.
Vatsvakurudzi vave kutarisa nezve "adoptive" NK cell therapy-kuunganidza NK masero kubva kune vanopa hukama hwepedyo uye kuvabaya muvarwere. Izvi zvakaratidza kuve zvakachengeteka, uye kusiyana neT cell therapy, NK masero haakonzeri chirwere chegraft-versus-host mumatishu anogamuchira.
Kuti uvandudze chiitiko uye huwandu hweNK maseru mumuviri, maJapan masayendisiti akagadzira nzira yekuwanza, inova yekubvisa 50ml kubva muropa remunhu, kupatsanura mashoma masero eNK uye nekuwedzera tsika kuwedzera nhamba kusvika yekutanga 1000 nguva, iyo nhamba inosvika bhiriyoni imwe kusvika kumabhiriyoni mashanu, uye yobva yadzokera mumuviri, huwandu hwakawanda hwemasero eNK anotenderera 1 kusvika ku5 nguva neropa mumuviri wese, kuuraya cancer maseru, maseru ekukwegura, maseru anorwara, mabhakitiriya uye mavhairasi mumuviri Zvakare, kuzadzisa chinangwa che anti-cancer uye anti-cancer, kugadzirisa hutachiona uye kuwedzera kurarama.
Parizvino, pane huwandu hwakawanda hweuchapupu hwekuti immunocytotherapy (NK maseru) nguva uye mushure mekuvhiyiwa inogona kudzora njodzi yekudzokazve uye metastasis.
Nei varwere vegomarara rechiropa vachinyanya kukodzera kurapwa kweNK cell
NK maseru, se "Molecular Patrol", inofamba muropa kwese kwese. Kana vachinge vawana masero ekunze kana masero akachinja ekuzvizivisa (anonzi MHC), iyo NK cell yekugamuchira inogamuchira pakarepo inotumira chiratidzo uye inomhanyira kune yakanangana nesero membrane Ndiko kuti, iyo NK maseru anofanirwa kunge ari kumberi mutsara iyo hondo. Inoburitsa maturu ane chepfu kwairi, nekukurumidza inoparadza maseru akanangwa, uye inoita kuti maseru ekenza afe mukati memaminitsi mashanu.
Izvo zvinofanirwa kucherechedzwa kuti NK maseru, sechikamu chepakati chemuviri wemuviri, ndiwo akakosha maseru ekuzvidzivirira emuviri mumuviri wemunhu, asi iwo mashoma kwazvo muropa revanhu, iro rinoverengera chete 5% -10% yema lymphocyte. Muchiropa, NK maseru anoverengera 30-50% yema lymphocyte.
Inofananidzwa nekutenderera NK masero, NK maseru muchiropa ane yakasarudzika phenotypic hunhu uye hunhu hunhu, kuratidza yakakwira cytotoxicity kune tumarara maseru.
During the occurrence of gomarara rechiropa, the proportion of NK cells and the function of cytokines (interferon-γ) production and cytotoxic activity are reduced.
NK masero anouraya sei cancer maseru?
Icho chikonzero nei maNK maseru anogona kuuraya maseru emukenza imhaka yekuyerwa kwemasaini eakagamuchirwa uye anodzivirira anogamuchira pamusoro peNK maseru. Yakagamuchirwa mamorekuru anoratidzwa pamusoro penzvimbo dzekenza maseru uye masero ane hutachiona uye anozivikanwa neNK maseru. Uye zvakare, maseru emukenza uye masero ane hutachiona anowanzo kurasikirwa neMHC I mamorekuru, zvichivaita kuti vabatike nekuzivikanwa kwesek.
NK masero aripo muropa revanhu uye "vanotanga kupindura.". Zvakafanana nemupurisa anga ari pabasa mumutumbi. Sezvo ropa richimhanya mhanya, NK masero anoramba achibata mamwe maseru paanenge achifamba. Kamwe kusarongeka kwawanikwa mumuviri Masero, anobva agadzikana, akarurama, asina tsitsi anomirira nguva yekutarisana nawo. Vanorwisa uye vanosunungura cytotoxic particles ine perforin uye granzyme pane yakanangwa sero membrane masero eT asati aiswa, zvichikonzera kuzviparadza kwekenza maseru. Vanogona zvakare kubvisa cancer stem maseru anotenderera mumuviri uye kubatsira kudzivirira metastasis.
Makomborero eNK cell therapy
1. Immune cell therapy ndiyo nzira yechina yekurapa mushure mekuvhiyiwa, chemotherapy uye radiotherapy. NK cell therapy inosanganiswa neradiotherapy uye chemotherapy inogona kunyatsobvisa masero emamota asingagoni kubviswa zvachose nekuvhiyiwa;
2. NK cell therapy inosanganiswa ne radiochemotherapy inogona kuvandudza kushanda kweradiochemotherapy uye kudzikisira mhedzisiro.
3. Kune varwere vegomarara repamberi vasina kukodzera kuvhiyiwa kana radiotherapy uye chemotherapy, NK cell therapy isarudzo iri nani;
4. Kugara uchirapwa neNK maseru mushure mekuvhiyiwa kunogona kudzivirira kudzokazve uye metastasis yekenza;
5.Sunungura marwadzo ekenza, kunatsiridza kurara, kugadzirisa hupenyu hwevarwere, uye kuwedzera hupenyu hwevarwere;
6. Kune vanhu vane utano hwakanaka, kushandiswa kweNK cell therapy kunogona kuderedza dambudziko rekenza.
Ndeapi varwere akakodzera NK cell kurapa?
Varwere vane hutano husina kunaka vasati vavhiyiwa, vanononoka kupora mushure mekuvhiyiwa, uye kutya kwemasero emukenza emashiripiti asiri kubviswa zvachose.
Mushure me radiotherapy uye chemotherapy, hutachiona hwakadzika, uye mhedzisiro iri pachena (senge kurasikirwa kwechido, kuda kurutsa, kurasikirwa nevhudzi, kuzvimba kweganda, nezvimwewo), nevarwere vanotarisira kuwedzera mhedzisiro yechemoradiation.
Nekuda kwekutya kwemhedzisiro ye radiotherapy uye chemotherapy, varwere vane tarisiro yekushandisa akasiyana marapirwo kuti vawane ekurapa mhedzisiro.
Cancer maseru mumatumbu epamberi akapararira mumuviri wese, asi zvakajairika nzira dzekurapa hadzina simba, uye varwere vanotarisira kuwedzera kupona nekuvandudza hupenyu.
NK cell kurapwa kurapwa maitiro
1. Kuunganidzwa kweropa
Dhirowa 30-50ml yeropa reropa o
f varwere vegomarara uye vanobvisa mononuclear maseru;
2. Kurima murabhoritari
Mu laboratori, ita NK cell induction uye kuwedzera kwemazuva mashanu kusvika mashanu;
3. Dzoka
Mushure mekunge iyo NK cell tsika yapera, inodzorerwa kumurwere wekenza sekuzadzwa.
