March 2023: Masayendisiti akagadzira mushonga mutsva unogona kushanda mukurwisa marudzi ose makuru ekenza yemapfupa muvana vakaudana kuti “mushonga unokosha zvikuru wakawanikwa munharaunda inenge hafu yezana remakore.”
Bvunzo pamakonzo akadyarwa negomarara remapfupa emunhu zvakaratidza kugona kweCADD522 kuvharidzira geni rine chekuita nekugona kupararira kwegomarara.
Zvakawanikwa, izvo zvakaburitswa muJournal yeBone Oncology, zvakaratidza, sekureva kwevaongorori, kuti mushonga unogona kuwedzera huwandu hwekupona ne50% pasina kudiwa kwekuvhiyiwa kana chemotherapy.
Lead researcher Dr Darrell Green, from the University of East Anglia’s Norwich Medical School, said: “Primary gomarara repfupa is a type of cancer that begins in the bones.
Kubudirira uku kwakakosha nekuti kurapwa kwegomarara remapfupa hakuna kushanduka kweanopfuura makore makumi mana nemashanu.
Dr Darrell Green
“Ikenza yechitatu inobata gomarara rakasimba muvana, mushure mehuropi neitsvo, paine vanhu vanosvika 52,000 XNUMX gore rega rega pasi rose.
“Inogona kukurumidza kupararira kune dzimwe nhengo dzemuviri, uye ichi ndicho chinhu chakanyanya kunetsa parudzi urwu rwegomarara.
"Kana gomarara rapararira, zvinova zvakaoma kurapa nechinangwa chekurapa."
Parizvino, chemotherapy nekudimburwa kwemakumbo ndiko chete kurapwa kwegomarara remapfupa, paine mukana we42% wekupona.
Maererano nevatsvakurudzi, "mushonga wavo unobudirira" unowedzera mararamiro ehupenyu ne50 muzana uye hauna migumisiro yakaipa yechemotherapy, yakadai sekudonha bvudzi, kuneta, uye kurwara.
Vatsvakurudzi vakaongorora sampuli dzemapfupa emapfupa kubva kuvarwere gumi nevapfumbamwe paRoyal Orthopedic Hospital muBirmingham nechinangwa chekudzidza.
Vakaona kuti jini RUNX2 inoshandiswa mugomarara remapfupa ekutanga uye inobatanidzwa nekupararira kwechirwere.
Zvinoenderana nemiedzo, CADD522 inodzivirira iyo RUNX2 protein kubva mukukurudzira kukura kwegomarara.
Dr. Green akati, "Kurarama kusina metastasis kwakawedzerwa ne50% mumatambudziko ekutanga apo mushonga mutsva weCADD522 wakashandiswa wega, pasina chemotherapy kana kuvhiyiwa.
“Ndine tarisiro yekuti ndikasanganiswa nemamwe marapiro akaita seoparesheni, hupenyu uhu huchawedzerwa.
"Zvakakosha, nekuti jini reRUNX2 hariwanzo kudiwa nemaseru akajairwa, mushonga haukonzere mhedzisiro senge chemotherapy.
Sezvo kurapwa kwegomarara remapfupa kusati kwachinja mumakore anopfuura makumi mana, kuwanikwa uku kwakakosha zvakanyanya.
According to the researchers, the drug is currently undergoing toxicology testing, after which the team will seek approval from the MHRA (Medicines and Healthcare products Regulatory Agency) to begin a kliniki yekuedzwa on humans.
Masayendisiti kubva kuYunivhesiti yeSheffield, Newcastle University, Royal Orthopedic Hospital yeBirmingham, uye Norfolk neNorwich Hospital vakapindawo mutsvakurudzo, iyo yakatsigirwa naSir William Coxen Trust uye Big C.
Dr. Green akataura kuti kufa kweshamwari yake yepamoyo kubva paudiki kenza yemapfupa kwakamukurudzira kuti adzidze nezvechirwere ichi.
“Ndaida kunzwisisa zvikonzero zvinoita kuti kenza ipararire kuitira kuti tigone kupindira mumakiriniki togadzira marapiro matsva kuitira kuti varwere vasazosangana nezvakaitwa neshamwari yangu Ben,” akatsanangura kudaro.
