Kukadzi 2024: Mishonga mitsva yakawanda uye marapiro anovimbisa, akadai chimeric antigen receptor T-cell therapy, vakaunza "renaissance" ye lupus, maererano nemukurukuri pahurukuro yeSimposium Basic uye Clinical Immunology yeBusy Clinician.
Sekureva kwaEmily Littlejohn, DO, MPH, weCleveland Clinic, monoclonal antibodies uye interferon ndiwo maviri ekuwedzera angangove ekurapa systemic lupus erythematosus ayo akabuda kubva 2020.
"2020 ndiyo iyo vazhinji vedu vanofunga nezve lupus renaissance," Littlejohn akaudza vaive pamusangano wehybrid. "Ino inguva apo, pakupedzisira, takava nemishonga yakawanda ichipinda muarmamentarium nekukurumidza."
Unogona kuda kuverenga: CAR T Cell kurapa muChina
Sekureva kwaLittlejohn, kwave nekurapa kutsva kwakawanda kunonakidza kweSLE kubva pakukurumidza kubvumidzwa kwebelimumab (Benlysta, GSK), voclosporin (Lupkynis, Aurinia), uye anifrolumab (Saphnelo, AstraZeneca). CAR T-cell therapy inogona kunge yakanyanya kunakidza pane izvi.
"Izvi zvinoshandiswa munyika yeoncology-takazviona mu [B-cell acute lymphoblastic leukemia], [B-cell non-Hodgkin's lymphoma] uye mantel cell lymphoma," Littlejohn akadaro. "Mubvunzo ndewokuti: Zvakadini nezvirwere zvedu?"
Littlejohn akataura kuti varwere vese vakapinda muchidzidzo cheGerman vakanyoresa varwere vashanu vane nhengo dzakawanda dzekubatanidzwa vakakwanisa kuwana nyika umo nephritis yakamira. Littlejohn akawedzera kuti mhedzisiro inopa tariro, asi kurapa hakuna njodzi.
Unogona kuda kuverenga: CAR T Sero kurapwa kweyakawanda myeloma muChina
"Pane njodzi huru yecytokine release syndrome - ICANS kunyanya - iyo inotyisa zvikuru," akadaro.
"Ndinofunga kuti pane vimbiso yakawanda munzvimbo ino, tichingofunga nezvevarwere vashanu ava [vakarapwa neCAR-T cell therapy] uye nemafambiro avakaita," akawedzera.
Dzimwe nzira ku CAR T-cell kurapa vari mubudiriro. Izvi zvinosanganisira litifilimab (BIIB059, Biogen), interferon-kinoid, obinutuzumab (Gazyva, Genentech) uye iberdomide (Bristol Myers Squibb).
Interferon-kinoid yakundikana kusangana nemagumo mumiedzo yakakosha, uye ramangwana rayo "harina chokwadi," Littlejohn akadaro.
Unogona kuda kuverenga: CAR T Cell kurapwa mutengo muChina
"Litifilimab yakatanga kudzidzwa muvarwere vane lupus, vanosvika zana nemakumi matatu nevaviri," Littlejohn akadaro. "Zvavakawana ndezvekuti zvakasangana nemagumo ekutanga nekudzikira kweganda CLASI mamaki pasvondo 132."
Pamusoro pezvo, mushonga uyu wakabudirira kudzikisa huwandu hwemajoini muchirwere chinoshanda, sekureva kwaLittlejohn akadaro.
Pakupedzisira, obinutuzumab yakasangana nemagumo ayo ekutanga muvarwere vane lupus nephritis, Littlejohn akadaro.
