Kukadzi 2024: Mesenchymal stem cells (MSCs) uye platelet-rich plasma (PRP) kurapwa kwakaratidza kugona mukurapa mabvi osteoarthritis (KOA) kuChina. Ongororo yemeta yezvidzidzo zvakadzorwa zvisina tsarukano zvakatarisa mukubudirira nekuchengetedzeka kweMSCs yakasanganiswa nePRP mukurapa KOA. Chidzidzo chacho chakawana kuti kusanganiswa kweMSCs nePRP kwakashanda muchipatara mukuderedza marwadzo uye kushanda pamwe chete muvarwere veKOA. Kurapa uku kwakakonzera kusave nemusiyano wakakura mumhinduro dzakaipa kana uchienzaniswa neMSCs chete.
Vatsvagiri veChinese vakaongororawo kushandiswa kweautologous bone marrow mesenchymal stem maseru akasanganiswa neplatelet-rich plasma yekurapa ibvi osteoarthritis, nemhedzisiro inovimbisa. Uyezve, tsvakurudzo yakatarisa mukushanda kweropa-rinotorwa mesenchymal stem masero akasanganiswa nevanopa-matched platelet-rich plasma mukurapa mabvi osteoarthritis.
Platelet-rich plasma therapy yagara ichishandiswa kurapa mabvi osteoarthritis, ine data inotsigira kushanda kwayo. PRP ine zvinhu zvinokura zvinokurudzira kugadziriswa kwematishu uye kuvandudzwa, zvichiita kuti ive chikamu chakakosha mukurapa osteoarthritis.
Finally, the combination of mesenchymal stem cells and platelet-rich plasma therapy shows promise for reducing pain, joint function, and tissue healing in Chinese knee osteoarthritis patients. Additional research and kliniki miedzo are required to validate and optimize this therapeutic strategy.
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Chii chinonzi mesenchymal stem cell therapy uye inoshanda sei?
Mesenchymal stem cell (MSC) kurapa kunoshandisa masero akura anogona kukura kuita bhonzo, cartilage, tsandanyama, uye mafuta maseru. MSCs dzakakosha mukurapa patsva nekuti dzinogona kuzvivandudza uye kusiyanisa mumitsara yakawanda. Aya masero anogona kuwanikwa kubva kumapfupa emapfupa, adipose tissue, kana umbilical cord tissue.
MSCs ine immunomodulatory masimba, zvinoreva kuti vanogona kudzora immune system kushanda, kuderedza kuzvimba, uye kudzvinyirira mhinduro dzeimmunological. Ichi chimiro chinoita kuti vagone kubatsira mukurapa kwe autoimmune kusagadzikana uye kurambwa kwekutapurirana. MSCs inogona zvakare kutsigira kugadzirisa kwematishu uye kuvandudzwa nekuburitsa zvinhu zvinokura uye ma cytokines, ayo anokwezva mamwe maseru kunzvimbo yakakuvadzwa uye kukurudzira kuvandudzwa kwetsinga dzeropa dzinodiwa pakugadzirisa matishu.
MSCs 'kurapa kwakanaka kunotemerwa nekugona kwavo kuenda kunzvimbo yakakuvadzwa, kunamatira, uye kunyora mune inotangwa tishu. MSCs zvakanyanya asiri-immunogenic nekuda kweiyo immunophenotype, zvichiita kuti ive yakanakira kurapwa-kwakavakirwa-sero muzvirwere zvakasiyana.
Nepo kurapwa kweMSC kwakaratidza vimbiso muzvidzidzo zvepreclinical zvekurapa kusagadzikana senge osteogenesis imperfecta, Chirwere cheCrohn, Multiple Sclerosis, Parkinson's, uye nevamwe, kudzidza kwakawanda kunodiwa kuti vanyatsonzwisisa kugona kwavo uye kugadzira mishonga yakachengeteka uye inoshanda. Kuti ive nechokwadi cheMSC kurapa kwakachengeteka uye kunoshanda kushandiswa mukurapa kwekuvandudza, zvakakosha kugadzirisa zvese zvakanakira uye zvinogona kugumira.
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Ndeapi marudzi akasiyana emesenchymal stem masero?
Mesenchymal stem masero (MSCs) ndiwo masero akura anokwanisa kuzvivandudza uye kusiyanisa mumhando dzakasiyana dzemasero. MaMSC akaiswa muzvikamu zvakasiyana zvichienderana nekwaanobva, imwe neimwe iine yayo seti yezvimiro uye mashandisiro:
1. Bone marrow-yakagadzirwa mesenchymal stem masero (BMSCs): Aya masero anonyanya kutorwa kubva mumwongo wemapfupa uye akaongororwa zvakanyanya nekuda kwesimba ravo rekuzvarwa patsva. Bone marrow stem masero anogona kusiyanisa kuita bhonzo, cartilage, adipose tishu, tsandanyama, uye mamwe maseru marudzi.
2. Adipose tissue-derived mesenchymal stem cells (ADSCs): ADSCs anotorwa kubva kune adipose tishu uye ane hunhu hwakafanana neBMSCs. Ivo vanogona kusiyanisa kuita akawanda masero emhando, zvichiita kuti ave anobatsira kune regenerative zvekurapa zvikumbiro.
3. Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSCs): UC-MSCs inotorwa kubva mumbilical cord tishu uye yakaratidza zvinokurudzira mhedzisiro muzvidzidzo. Aya maseru ane mutsauko wemitsara yakawanda uye anogona kukura kuita bhonzo, cartilage, tsandanyama, uye mamwe marudzi esero.
Mhando yega yega yeMSC ine hunhu uye mabhenefiti akasiyana, zvichiita kuti ive yakakosha kune akasiyana ekurapa ekushandisa. MaMSC ane hukuru hwakakura mukurapa kwekuvandudza nekuda kwekugona kwavo kupatsanura mumarudzi akawanda emasero uye kugona kwavo immunomodulatory. Kumwe kuongorora kuri kuitwa kuona kugona kwakazara kwekurapa kwemhando dzakasiyana dzeMSC mukurapa huwandu hwakawanda hwezvirwere uye kusagadzikana.
Ndezvipi zvinokonzerwa ne mesenchymal stem cells (MSC) uye platelet-rich plasma (PRP) therapy?
Mesenchymal stem masero (MSC) uye platelet-rich plasma (PRP) kurapwa kwakaratidza kuvimbiswa mukurapa kwakasiyana siyana kwezvirwere, asi zvakakosha kuti tiongorore mhedzisiro inogona kuitika. Zvinoenderana netsvagiridzo, kusanganiswa kweMSCs nePRP mukurapa mabvi osteoarthritis kwakaratidza kugona kwakanaka kwekiriniki maererano nekunyaradza marwadzo uye kushanda kwemajoini, pasina mutsauko wakakura mumhedzisiro yakaipa kana ichienzaniswa neMSC chete.
Kunyange zvazvo PRP yakaratidza kuchengetedzwa kwakanaka uye kushanda zvakanaka mukurapa mabvi osteoarthritis, rubatsiro rwekurapa runogona kuderera sezvo zera remurwere rinowedzera. Uyezve, tsvagiridzo yakaratidza kuti PRP inogona kukurudzira kuwanda uye kusiyanisa kweMSCs, iyo inogona kubatsira mukupora kwetishu. Nekudaro, zvakakosha kuyeuka kuti zvine chekuita nejekiseni mhedzisiro, senge kusagadzikana, kukuvara kwetsinga, uye kubuda kweganda, zvinogoneka asi zvisingawanzo.
Uyezve, kana uchiongorora maitiro eMSCs uye PRP kurapwa pakupora kweronda rekucheka, zvakakosha kuti uongorore senescence uye hukuru hwesero kugona kudzivirira mhedzisiro yakaipa uye zvisizvo zvinotarisirwa kubva musero kurapwa. Kunyatsoongorora uye kunzwisisa kwakabva masero anoshandiswa mukurapa kunogona kubatsira kuderedza migumisiro isina kunaka.
Mukupedzisa, nepo MSCs uye PRP therapy ine mukana wekubatsira akasiyana mamiriro, anosanganisira kuporesa maronda uye osteoarthritis, zvakakosha kuti uzive zvingangoitika mhedzisiro uye kuve nechokwadi chekuongorora kwakaringana nekutarisisa kuitira kuti kuwedzere kushanda kwavo uku uchideredza njodzi.
Ndeipi mutengo weMSC uye PRP wemabvi osteoarthritis muChina?
A unilateral MSC uye PRP therapy yemabvi osteoarthritis muChina inodhura madhora mazana manomwe emadhora uye mativi maviri anodhura madhora zviuru zana nemazana maviri.
