July 2021: Tarisa mishonga ichangoburwa mukurapa cancer. Gore rega rega, mushure mekuongorora miedzo uye zvimwe zvinhu zvakakosha, iyo USFDA inobvumira zvinodhaka, uye nokudaro varwere vekenza zvino vanogona kutenda kuti kurapa kwava pedyo zvikuru.
Mumakore achangopfuura, zvakawanda zvakaitika kuchinja nzira iyo hosha yacho uye ichabatwa nayo. Nekuda kweizvozvo, vanhu vane cancer nevarapi vavo vane sarudzo dzakawanda dzekusarudza kubva uye nezvimwe munzira.
Tarisa: Mutengo wekurapa kenza muIndia
Kugona kwemasero ako kunzvenga immune system yako chimwe chinhu chinoita kuti kurwisa cancer kunetse. Muviri wako hauvaoni sekutyisidzira, kana kuti haugone kushanda kuti urwise zvakanyanya.
Asi masero aya "akaiswa chiratidzo" nemamwe emazuva ano immunotherapy mishonga, saka ari nyore kuwana. Mishonga iyi inogonawo kuita kuti dziviriro yemuviri wako isimbe kuitira kuti irwise mamota.
Mhando iyi yekurapa yakatoshanda kune mamwe marudzi egomarara. Mimwe mishonga yakawanda iri mumabasa.
Mhando yekurapa kwemajini inonzi CAR T-cell kurapa yakatenderwa ne FDA. Inoshandisa mamwe maseru ako ekudzivirira kurwara nekenza yako, inonzi T masero. Nekuisa majini matsva, vanachiremba vanoburitsa maseru muropa rako voachinja kuti vakwanise kuziva nekuparadza maseru egomarara nekukurumidza.
Tarisa: Mutengo weCAR T-cell kurapwa kweacute lymphoblastic leukemia (ALL) muIsrael
Mushonga unonzi tisagenlecleucel (Kymriah) parizvino wakatenderwa kurapwa kweB-cell acute lymphoblastic leukemia muvana nevechidiki vanosvika makore makumi maviri nemashanu vasina kufambira mberi nemamwe marapirwo. Asi kune vakuru uye mamwe marudzi egomarara, masayendisiti ari kushanda pane akasiyana eCAR T-cell therapy.
Tisagenleucel uye axicabtagene (Yescarta) ese ari maviri anotenderwa kurapa mamwe marudzi evakuru B-cell lymphoma ayo mamwe marapirwo asina kukwanisa kubatsira.
Tarisa: Mutengo weCAR T-cell kurapwa muChina
Mushonga mutsva wakadanwa brexucabtagene autoleucel (Tecartus) nguva pfupi yadarika yakagamuchirwa neFDA mune varwere vane mantle cell lymphoma vasina kufambira mberi nemamwe marapirwo kana kuti vakadzoka mushure mekurapwa.
Chirwere chegomarara chichiri chakavanzika chisina kugadziriswa, uye masayendisiti, varapi, uye makambani pasi rese vachiri kutsvaga kuwana mushonga unobvira wechirwere chinouraya ichi. Kubva pari zvino, chemotherapy ndeimwe yezvishandiso zvinonyanya kushanda mumaoko enyanzvi dzegomarara muIndia nepasirese, avo, kana vakaonekwa nekukurumidza, vanogona kurwisa chirwere ichi kusvika pamwero mukuru. Takaona mishonga mitsva yakawanda ichibuda mumakore mashoma apfuura kurwisa cancer maseru. Izvi zvinodawo kurapwa kwakanangwa kunovavarira kurwisa maseru chaizvo, zvichibvumira maseru akajairwa kuti asanyanya kukuvara. USFDA yakabvumidzawo kubvumidzwa kwayo kwekutanga gene alteration therapy gore rino muna 2017, ichichinja t masero evarwere kuti inyatsoshanda kurwisa cancer.
Muna 2017, USFDA yakapa mvumo kune mimwe mishonga yavanotenda kuti ichaita mutsauko mukuru mukurapwa kwegomarara. Vari:
- Bavencio (Avelumab) - gomarara redundiro
- Kisqali (Ribociclib) - Gomarara rezamu
- Nerlynx (Neratinib) - Gomarara repazamu
- Rydapt (Midostaurin) - Leukemia
- Besponsa (Inotuzumab Ozagamicin) - Leukemia
- Kymriah (Tisagenlecleucel) - Leukemia
- Tafinlar (Dabrafanib) – kenza yemapapu
- Mekinist (Trametinib) - Kenza yemapapu
- Opdivo (Livolumab) - Kenza yechiropa
- Yescarta (Axicabtagene ciloleucel) - Lymphoma
- Kuwanda (Acalabrutunib) - Lymphoma
- Bavencio (Avelumab) - Merkel cell carcinoma
- Zejula (Niraparib) - Ovarian cancer
- Keytruda (Pembrolizumab) – Gomarara remudumbu
