Cancer kuberekwa kuongorora
Cancer gene yekuongorora madhairekitori anonangwa kurapwa seyakakosha tekinoroji yekunyatso kurapa cancer. Wese murwere wegomarara anofanirwa kuzviitira kuongororwa gene, achitsvaga anoshanda akananga mishonga uye miedzo yekiriniki yekurapwa. Global Oncologist Network, yakabatana neUS genetic test agency uye yepamba yepamusoro-notch genetic test agency, inopa varwere vane chokwadi chegomarara rekuongorora genetic uye masevhisi ekubvunza nyanzvi kubatsira varwere kugadzira hurongwa hwekurapa hwakanyanya.
Iyo FDA nguva pfupi yadarika yakabvumidza Iressa senge imwe-mumiriri kurapa metastatic isiri-diki cell cell cancer cancer (NSCLC) yakanaka kune epidermal growth factor receptor (EGFR) shanduko yakasimbiswa neFDA-yakatenderwa shamwari yekuongorora kit.
Iressa ndiyo yekutanga mushonga wakanangwa nemamolecular kurapa cancer yemapapu muChina. Yakatangwa zviri pamutemo muChina nemvumo yeState Food and Drug Administration muna 2005, ichivhura nguva nyowani yekurapa varwere vane gomarara remapapu risiri diki. Iressa inounza dzimwe nzira dzekurapa dzakakwenenzverwa kune varwere vekenza yemapapu muChina kuti vavandudze hupenyu hwavo uye vane tsika yekurebesa kurarama kwavo. Pamakore matanhatu ekuyeukwa kwekunyorwa kweIressa, Iressa akabvumidzwawo semutsetse wekutanga kurapwa kweasiri-diki kenza yemapapu.
Chirwere chegomarara remapapu ndiyo nhamba yekutanga yegomarara pakati pehuwandu hwekufa hunoenderana nebundu muChina. Isiri-diki kenza yemapapu yemapapu (NSCLC) inoverengera ingangoita 85% yekenza dzese dzemapapu.
Parizvino, kurapwa kwegomarara remapapu kuchiri kunyanya kuvhiyiwa, kurapwa nemwaranzi, uye kurapwa kwezvinodhaka. Kurapa kwemishonga yekenza yemapapu kunosanganisira chemotherapy uye molecularly targeted drug therapy (yakajairika kuEGFR-TKIs).
Kurapwa kwekenza yemapapu, kunyanya isiri-diki kenza yemapapu, inotsigira mhando yekurapa yega. Izvo zvinoenderana nemutyairi gene kutaura chimiro chevarwere vekenza yemapapu, ndiko kuti, kurapwa kwakasarudzika zvichienderana nekuti varwere vekenza yemapapu vane majini emutyairi. Pakati pavo, epidermal growth factor receptor (EGFR) ndeye tyrosine kinase receptor, uye nzira yayo yekufambisa chiratidzo inogadzirisa kukura kwesero, kupararira uye kusiyanisa. Mukenza, inowanikwa kuti kuchinja kwakasiyana-siyana kunowanzoitika munharaunda yeEGFR tyrosine kinase. Idzi shanduko dzakabatana zvakanyanya nekushanda kwe tyrosine kinase inhibitors. EGFR mutation chinhu chakakosha mutyairi wegomarara. EGFR mutation inoratidzira yakasimba yekuti varwere vekenza vanonzwa neTKI. Naizvozvo, kuongororwa kweEGFR gene mutations kunogona kupa hwaro hwebundu rakanangana nekurapa. Iyo EGFR mutation mwero wevarwere vekenza yemapapu muChina ndeye 30% -40%.
EGFR gene mutation saiti inoona kana vasiri diki-diki cell cancer yemapapu varwere vanogona kushandisa Iressa, Tarceva nemimwe mishonga yakanangwa. Iressa / Trokai shanduko mune exons 18, 19, 20, uye 21, kunyanya kubviswa kweexon 19 kana shanduko yeexon 21, kune zvakakosha. Zvinokurudzirwa kuti varwere vane isiri-diki kenza yemapapu vatarise genetic vasati vashandisa zvinodhaka zvakanangwa seIressa / Troca.
