George D. Demetri nevamwe vanobva kuAmerican Dana Fabre / Briegen uye Women's Hospital Cancer Center vakashuma kuti pakati pevarwere vane liposarcoma, kushandiswa kweiriprine mukurapa kwemashure kwakagadzirisa zvakanyanya mararamiro ekupona pane dacarbazine. Kune varwere vane liposarcoma, chinhu chakanyanya kukosha kusarudza kurapwa kweiribrin, nekuti rudzi rwechirwere rwechirwere rune hushoma pane kugona. (J Clin Oncol. Online vhezheni Nyamavhuvhu 30, 2017)
Chikamu chekare chechikamu chechitatu chemakiriniki chakaratidza kuti irribrin ichienzaniswa nedacarbazine pakurapa kwepamberi liposarcoma kana leiomyosarcoma inogona kuvandudza zvakanyanya kupona kwese (OS), uye maitiro akashata ari nyore kubata uye kutonga. Iye zvino vaongorori vakaita ongororo yesekisheni yemamiriro eboka iribulin neboka re dacarbazine, nechinangwa chekujekesa chakanangana nematinji uye kuchengetedzeka.
Kunyoresa mamiriro: zera remurwere ≥18 makore; advanced kana advanced liposarcoma isingagoni kurapwa nekuvhiyiwa kana radiotherapy; ECOG performance status ≤2; yapfuura chemotherapy regimens ≥2, kusanganisira anthracycline. Varwere vakapatsanurwa zvisina tsarukano muboka re erebrin (1.4 mg / m2, d1, 8) kana dacarbazine boka (850 mg / m2, 1000 mg / m2, kana 1200 mg / m2, d1) muchiyero che1: 1. Mazuva makumi maviri nerimwe idenderedzwa. Zvidzidzo zvekupedzisira zvinosanganisira OS, kufambira mberi-kusina kupona (PFS), uye kuchengeteka.
Mhedzisiro yacho yakaratidza kuti OS iri muboka re liposarcoma yakavandudzwa zvakanyanya. Iyo yepakati OS mune iribulin uye dacarbazine mapoka aive 15.6 mwedzi uye 8.4 mwedzi, zvichiteerana (HR = 0.51, 95% CI 0.35 ~ 0.75; P <001). Mune iribulin boka, varwere vane liposarcoma yeese histological subtypes uye varwere mumatunhu ese vakawana OS kuvandudzwa. Iyo yepakati PFS yevarwere muboka rererebrin yaive 2.9 mwedzi uye 1.7 mwedzi inoenderana neboka re dacarbazine (HR = 0.52, 95% CI 0.35 ~ 0.78; P = 0.0015). Zviitiko zvakashata zvaive zvakafanana pakati pemapoka maviri aya.
