Kuzvimba kwenguva refu chinhu chinofanobata chegomarara re colorectal, inova yechitatu inotungamira zvikonzero zvekufa kwekenza muUnited States. Dr. Anna Means nevamwe vaaishanda navo vakashuma mupepanhau Cell and Molecular Gastroenterology and Hepatology mwedzi wapera kuti vakabatanidza kuputika-inotungamirirwa necarcinogenesis yekoloni nekurasikirwa kweprotein inokosha yechiratidzo inonzi SMAD4. SMAD4 chikamu chekuchinja kwekukura kwechikonzero β (TGF-β) chiratidzo chenzira, iyo inogadzirisa maitiro ekudzivirira uye ekuputika kune utachiona mu colonic epithelium.
Kubviswa chaiko kweiyo SMAD4 geni mune yakajairwa mbeva colon epithelial maseru akakura mu vivo kwakawedzera kutaura kweanopisa vamiririri. Mune mbeva dzevanhu vakuru nekuzvimba, kushomeka kweSMAD4 kunoguma mukufanana kunoshamisa pakati pemamota nemakenza anosangana necolitis yevanhu.
Loss of SMAD4 was also observed in 48% of human colitis-related cancers, compared with 19% of scattered kenza dzakajeka. “This loss may be an important factor from premalignant lesions to aggressive malignant tumors,” the researchers concluded. Therefore, friends with chronic inflammation must eliminate inflammation in time, and do not regret it until the inflammation develops into cancer.
