Dova Pharmaceuticals yakataura kuti US Food and Drug Administration (FDA) yakabvumidza mahwendefa matsva eAkaRx's Doptelet (avatrombopag) ekurapa mashoma eplatelet count (thrombocytopenia) muvakuru vane chirwere chisingaperi chechiropa (CLD) vanozovhiyiwa kenza kana. zino. Zvakakosha kutaura kuti uyu ndiwo mushonga mutsva wechitatu wakabvumidzwa neFDA mukati mesvondo uye mushonga wekutanga wakatenderwa kuita izvi.
Platelets masero asina ruvara anogadzirwa mumwongo anobatsira kuumba magwamba eropa mutsinga uye kudzivirira kubuda ropa. Kenza chemotherapy inowanzokonzera thrombocytopenia.
Doptelet (avatrombopag) chizvarwa chechipiri, kamwe-zuva nezuva muromo thrombopoietin (TPO) receptor agonist. Doptelet inogona kutevedzera zvinoitwa neTPO, ndiyo inonyanya kugadzirisa zvigadzirwa zvakajairika zveplatelet. Mushonga uyu wakapihwa pekutanga ongororo yekukodzera kurapa thrombocytopenia kune vanhu vakuru vane CLD vanozovhiyiwa.
Kuchengeteka uye kushanda kweDoptelet kwakasimbiswa mumiedzo miviri (ADAPT-1 uye ADAPT-2). Izvi zvidzidzo zvaisanganisira huwandu hwevarwere mazana mana nemakumi mashanu nemashanu vane chirwere chisingaperi chechiropa uye zvakanyanya thrombocytopenia, vanozovhiiwa izvo zvinowanzoda kuwedzerwa platelet. Iyi miedzo yakaongorora mhedzisiro yemuromo doptelet pamatanho maviri emazinga achienzaniswa ne placebo kwemazuva mashanu ekurapwa. Mhedzisiro yacho yakaratidza kuti zvichienzaniswa neboka re placebo, yakakwira muzana yevarwere mune maviri-dose mwero weDoptelet boka rakawedzera huwandu hweplatelet uye vaisada kugamuchira platelet kuwedzerwa kana chero kurapwa kwekununurwa pazuva rekuvhiyiwa uye mukati memazuva manomwe mushure mekurapwa . Mhedzisiro inowanzoitika yeDoptelet fivha, mudumbu (mudumbu) kurwadziwa, kuda kurutsa, kurwadziwa nemusoro, kuneta, uye kuzvimba kwemaoko nemakumbo (edema).
"Varwere vane yakaderera maplatelet kuverenga uye chisingaperi chirwere chechiropa chinoda kuvhiyiwa vane mukana wakawanda wekubuda ropa," akadaro Dr. Richard Pazdur, director weCentre for Excellence muOncology uye anoita director weHofisi yeHematology uye Oncology Zvigadzirwa kuFDA Center Yekuongorora Zvinodhaka uye Ongororo. Wedzera iyo platelet kuverenga. Mushonga uyu unogona kudzora kana kubvisa kudiwa kwekuiswa kweplatelet, (kuisirwa platelet) kunogona kuwedzera njodzi yekutapukirwa uye kumwe kushushikana.
