Chidzidzo chitsva chinotsanangura hukama hwemechanistic pakati pethecytokine interleukin-1β (IL-1β) uye kufutisa. KanaIL-1βlevels inowedzera mukufutisa, iyo activation yeIL-1 receptor siginecha inotungamira kune yakakura nhamba yecolon cancers. Mhando dzenzira. Ichi chidzidzo chinoratidza kuti kufutisa kwakabatana nekuwedzera kwesystemic yeIL-1β, iyo activation yeW uye kuwanda kwembeva colon masero.
Joel Mason weYunivhesiti yeTufts muMassachusetts uye Tufts University Chikoro cheMishonga uye vaaishanda navo kuTufts University vakanyora chinyorwa ichi "Interleukin- 1 Signaling Mediates Obesity-Inosimudzira Yakawedzera Inopisa MaCytokines, Wnt Activation, uye Diki" Kuwedzera kwegonzo colonic epithelial maseli "chinyorwa . "
The researchers set out to determine the role of IL-1β in regulating events leading to obesity-promoting kenza yakajeka. They compared the role of IL-1β in mice fed a high-fat (obese) or low-fat (lean) diet. One of the changes they are found in obese mice having colon mucosa 30-80 % higher concentration of IL-l [beta] , the Wnt cascade significantly increased signal amplification and significantly proliferating crypts in the colon region.
"Ichi chidzidzo chinoburitsa hukama hwepedyo pakati pekufutisa uye kupindura kwekuputira, uye inoratidza basa rakakura reI-1β, kutsanangura kufutisa seimwe yezvirwere zvakawanda zvinopisa," Dhipatimendi reImunology, Washington University, Center for Innate Immunity uye Immune Zvirwere. Michael Gale Jr., mupepeti-mukuru weJenali yeInterferon & Cytokine Research, akadaro.
