Pamusangano we2018 ASCO, mhedzisiro yeongororo yechemotherapy yakakwezva vanhu vazhinji. Zvidzidzo zvakaratidza kuti innovative chemotherapy inogona kurapa cancer yepancreatic inozivikanwa se "mambo wegomarara". Kune iri gomarara rine fungidziro yakaipa kwazvo, iyi chemotherapy inogona kurebesa hupenyu hwemurwere kusvika kumwedzi makumi maviri!
Muchiedzo chekiriniki chinonzi PRODIGE 24 / CCTG PA.6, vatsvakurudzi vakatsvaga nhamba huru yevarwere vane non-metastatic pancreatic duct adenocarcinoma (PDAC), iyo ndiyo inowanzoita kenza yepancreatic, inoverengera 90% yezviitiko zvose. %. Varwere ava vakavhiyiwa kubvisa bundu. Mumavhiki matatu kusvika gumi nemaviri mushure mekuvhiyiwa, vese varwere ve3 vakakamurwa zvakasiyana mumapoka maviri, rimwe boka rakagamuchira gemcitabine (gemcitabine) kurapwa, rimwe boka rakagamuchira chemotherapy nyowani mFOLFIRINOX (yakagadziridzwa FOLFIRINOX) kurapwa. Iyo yekupedzisira ine ina dzakasiyana dzakasiyana chemotherapy zvikamu, zvinosanganisira oxaliplatin, leucovorin, irinotecan, uye 12-fluorouracil.
Chidzidzo chacho chakaratidza kuti nekuteedzana kwepakati pemwedzi makumi matatu nematatu nematanhatu, iyo yepakati-isina chirwere chisina chirwere chevarwere muboka reFOLFIRINOX chaive chakakwirira zvakanyanya kupfuura icho cheiyo gemcitabine boka (33.6 mwedzi -21.6 mwedzi). Panyaya yekupona kwepakati nepakati, iyo yekutanga yakatokwira kupfuura mwedzi yapfuura makumi maviri (20 mwedzi-54.4 mwedzi). Nemamwe mabhenefiti ekupona, mhedzisiro yemakemikari anokwanisa kudzorwa.
Zvinoenderana nechirongwa ichi, vaongorori vacharamba vachiongorora nguva yakanakisa yekemotherapy kuitira kuti vanzwisise kuti varwere vanogona kupihwa chemotherapy vasati vavhiyiwa kuti vadzike bundu, nokudaro vachideredza njodzi yebundu micrometastasis uye kuwedzera mukana wekuti bundu racho ribviswe zvachose kuvhiya. Tinotarisira kunzwa mamwe mashoko akanaka nezvechirwere ichi uye rega varwere vane chirwere chepancreatic cancer vaone tariro.
