Yunivhesiti yeTexas MD Anderson Cancer Center uye Takeda Pharmaceutical Kambani Zvishoma zvakapinda mukunzwisisa kunoganhurira uye mvumo yekutsvagisa kugadzira uye kutengesa chimeric antigen receptor inotungamirwa muurayi wechisikigo (CAR NK) - masero ekurapa.
Pasi pekunzwisisa, Takeda achawana mukana wekurapwa kwaMD Anderson kuitira kuti agadzire uye atengese CAR NK-cell marapirwo anosvika mapurojekiti mana, sezvakaratidzwa nechiziviso chakaitwa neChipiri kureva 4 Kukadzi. uye kuzvipira mukugadzira chizvarwa chinotevera chekurapa kwesero, Takeda ndiye mubatsiri akakodzera kubatsira timu yedu kufambisa CAR NK-sero kurapwa kune varwere vanoda kurapwa, "akadaro Katy Rezvani, MD, PhD, purofesa we stem cell transplantation uye cellular therapy. uye MD Anderson.
Iyo yekurapa ine nzira yekuenzanisa kune yakanyanya-yakashambadzirwa CAR T-cell kurapwa, iyo inoratidza yakakosha vimbiso mune dzakawanda zvirwere, nekuunganidza mamwe machena maplatelet evarwere, achivashongedzera neakanangidzirwa pamusoro pemvura ekurwira kurwisa chaiko kwakashata kukura, uye mushure mekuzadza. ivo zvakare muropa remurwere.
Zvingave zvakadaro, chemotherapy inogona kusiya varwere vashoma vasina kukwana autologous T masero muropa ravo kuti varapwe CAR T-sero kurapwa, nepo vamwe vangave vasina mukana unodiwa kuti lab igadzire masero eT akakwana, sezvakaratidzwa nevanoongorora.
Mota NK-cell kurapwa, yakagadzirwa kuMD Anderson, inoshandisa akajairwa maseru ekuuraya kubva patambo yeropa. Boka rakati rinotendera kuburitswa kwekurapwa kusingafanirwe kunge kuchiitirwa murwere mumwe nemumwe - uyezve kunodzivirira mukana wekujoinha kana chirwere, inova njodzi ine mamwe maT-cell assortment.
MD Anderson boka rakashandisa retrovirus kuunza hutsva hutsva mumasero eNK: CD19 inowedzerwa kuwedzera CAR NK kujekesa kweB-cell malignancies; interleukin 15 (IL15) inowedzerwa kuti ibudise huripo hwemafoni mumuviri; uye CASP9-yakavakirwa "mhando yekuzviuraya" senzira yekudzivirira, iyo inogona kukonzeresa kukonzeresa apoptosis nediki atomu dimerizer kana paine muchetura kunaka mushure mekuiswa.
Mukutaura manzwisisiro aya, MD Anderson naTakeda vakasimbisa kuti kurapwa kweCAR NK kunogona kudzorwa kunzvimbo dzevarwere.
Kusvika parizvino, kurapwa kwaratidza kwakachengeteka: Inofambira mberi nhanho I / 2a kiriniki kuongororwa mune varwere vane backslid uye misoro B-cell malignancies yakaratidza kuti CD19 CAR NK-kurapwa haina kunge yakabatana neakanyanya cytokine kubuda chirwere kana neurotoxicity yakaona ne huripo kurapwa kweCAR-T.
Takeda vakati vane tarisiro yekutangisa kuferefetwa kwakakosha kweCD19 CAR NK-cell kurapwa muna 2021.
Unogona kuda kuverenga: CAR-NK Cell kurapwa
MD Anderson anowana chikamu chaicho chakange chisina kujekeswa nekuungana sechimwe chikamu chegadziriro, sezvakangoita zvakasarudzika masimba pamabatiro emambure, sezvakaratidzwa nechiziviso.
Rezvani akati chinangwa ndechekugadzira mishonga inosvika kuvarwere uye pakupedzisira inochinja hupenyu.
"Chiono chedu ndechekuvandudza marapirwo aripo nekugadzira zvombo zveCAR NKs zvinogona kupihwa kunze kwesherufu munzvimbo yekunze, zvichiita kuti varwere vazhinji varapwe zvinobudirira, nekukurumidza, uye nehuturu hushoma," akadaro Rezvani.
