Bone marrow fibrosis chirwere chisingawanzoitika chefupa remongo wehematopoietic maseru. Ivo vanobatsirwa kubva kuJAK2 inhibitor zvinodhaka: chiratidzo chekusununguka, kurarama kwenguva refu, uye nekuvandudza hupenyu hwehupenyu. Zvisinei, makore maviri kana matatu mushure mekutanga kurapwa, vamwe varwere vanoita hutsinye B-cell lymphoma. Mukubatana kwepedyo nevatsvakurudzi muVienna, MedUni uye Vetmeduni, JAK2 inhibitors yakamutsa "yakarara" lymphoma uye kenza mumapfupa emapfupa kekutanga.
Kushandisa bone marrow biopsy pakutanga kwechirwere, 16% yevarwere vane myelofibrosis vakawanikwa vane dormant aggressive lymphoma. Munenge 6% yevarwere ava, kana ikakurudzirwa neJAK2 inhibitors, inoputika. Sekureva kwevanoongorora hematologists, kana hunyanzvi hwemamolecular biology hukashandiswa kushingaira kutsvaga latent lymphoma, zvinokwanisika kuona yakarara lymphoma. Ichi ndicho chakanakisa chekufungidzira chishandiso chinotibvumira kuongorora 16% yevarwere vanoonekwa sevarwere vane njodzi yakanyanya vasati varapwa neJAK2 inhibitors.
Izvo zvakaratidzwa mune yegonzo modhi iyo mbeva idzo dzainge dzave nekugadziriswa kwemongo wemapfupa dzakagadzirawo lymphoma. Kubatana kwakasiyana siyana muenzaniso wakanaka wekuti kutsvagurudza kwave kuvhurika sei uye kukosha kwekutsinhana kwedata mumushonga. Nhanho inotevera: kuunganidzwa kwenyaya dzepasi rose uye data rakanangana naro rakatanga kuwedzera kunatsiridza kuchengetedzwa kwezvinodhaka, uye vaongorori vari kushanda pamwe nemakambani emishonga anogadzira aya akajairika madhiragi. Gadzira bhiriji rinokurumidza, rinoshanda uye rinoputsa pasi pakati pemakonzo emakonzo uye zvakawanikwa zvekiriniki, uchibatanidza zvakakwana kutsvagisa kwekutanga, prelinical uye kiriniki basa kubatsira varwere vegomarara.
