Pa18th World Congress yeGastrointestinal Cancer, chikamu chekutanga chekiriniki chidzidzo chakaratidza kuti anti-PD-L1 immunotherapy yakasanganiswa neMEK inhibitors inogona kunyatso kurapa microsatellite yakagadzikana metastatic colorectal cancer.
Mupurisa anotungamira wechidzidzo ichi, Johanna Bendell weSarah Cannon Cancer Institute, akati: Parizvino, immunotherapy yakangoshanda chete kune varwere vane gomarara rakakura risingagadzike remacrosatellite, uye rudzi urwu rwevarwere vanongoita 5% chete yevagari.
Yakanyanya microsatellite isina kugadzikana colorectal cancer ine nhamba yakakura yekuchinja uye nekudaro inopindura anti-PD-1 / PD-L1 immunotherapy. Nekudaro, vangangoita 95% yevarwere vane metastatic colorectal cancer vane microsatellite yakagadzikana foci. Parizvino, chikamu ichi chevarwere hachina kumbopindura kune immunotherapy.
Zvidzidzo zvepamberi zvinoratidza kuti MEK inhibitors inogona kuita kuti mamota anzwe zvakanyanya kune immunotherapy. Iyo chaiyo nzira inogona kunge iri yekuwedzera huwandu hweanoshanda immune maseru (senge CD8 akanaka maseru) mune bundu uye kuwedzera kutaura kwe pro-immune system activation zvinhu.
Mhedzisiro yenyaya iyi yakaratidza kuti iyo Phase I b kiriniki yekudzidza yakashandisa iyo MEK inhibitor Cobimetinib kurapa 23 varwere vane kenza yekurapa yakajeka maererano nedosi-yekukwira regimen. (Q3W), varwere vazhinji vanogona kushivirira madhizaini makuru uye vanorapwa ne800 mg yePD-L1 inhibitor Atezolizumab (jekiseni rinopinza, Q2W).
Mukurapa kwekutevera, vaongorori vakaona kuti varwere vana (4%) vaive nebundu shrinkage inosvika makumi matatu%, uye vashanu varwere (17%) vaive nezvirwere zvakagadzikana. Iyo inoenderera yekuregererwa nguva inopfuura 30 ~ 5 mwedzi. Sezvo yedhata razvino, vaviri pavane varwere vane kuregererwa zvishoma vakawana kuregererwa kusingaperi. Pakati pevarwere vane kuregererwa zvishoma, matatu makesi aive microsatellite yakagadzikana kana yakaderera-chikamu microsatellite kusagadzikana, uye 22 kesi yaive isingazivikanwe microsatellite mamiriro. Pakati pevarwere vakasanganisirwa muchidzidzo, pakanga pasina zviitiko zvema microsatellites asina kugadzikana.
Uye zvakare, hwaro hwepakutanga hwePD-L1 hahukanganisi kuregererwa kwezvirwere, mushonga wekubatanidza unoregererwa zvakanaka, uye hapana zviitiko zvakakomba zvine chekuita nekurapa.
Bendell akagumisa achiti: "Mhedzisiro yechidzidzo ichi inoenderana nefungidziro yemubatanidzwa wekurapa, iyo inopawo imwe 95% yevarwere vegomarara vane kenza mukana wekubatwa nemushonga." Iye muongorori ave kuda kuvhura chikamu chechitatu chekiriniki yekudzidza, kuronga kupinda muboka iri kwakaoma Kune inorapa metastatic colorectal cancer, enzanisa kushanda kweiyi yekubatanidza kurapa neyakajairwa marimu.
