Vashandi vezvokurapa pasi rose vari kugadzira mishonga mitsva yekudzivirira vanhu, kusanganisira marudzi akasiyana-siyana ekudzivirira kenza nekurapa. Dzvanya kuti uwane ruzivo: Chiedza chetariro yekupedza cancer-2019 yepasi rose hesiti yeazvino cancer yekudzivirira! (Kuvhara magomarara makuru matanhatu).
Immune cells (pink and red) attack tumarara cells (blue) that produce new antigens (blue and orange). Vaccines can help train immune cells to recognize new antigens.
Recently, scientists have developed a vaccine that can destroy the mutant cells made by Lynch syndrome (Lynch) DNA in mice, and may one day prevent people with the genetic disease Lynch syndrome from developing kenza yakajeka.
Chidzidzo ichi chakazivisa kuti mune yeLynch syndrome (Lynch) mbeva modhi, kubaiwa nhomba nemashoma mana mamota maantigen kunogona kuburitsa antigen-yakanangana nemhinduro, kudzora matumbo matumbo, nekuvandudza kupona.
According to the data provided by the recent AACR annual meeting, this pre-human study shows that it is possible to develop a vaccine to prevent cancer in patients with Lynch syndrome.
Carcinogenic genetic chirwere-Lynch syndrome
Lynch syndrome, commonly referred to as hereditary nonpolyposis colorectal cancer (HNPCC), is an inherited disease that may be caused by mutations in genes inherited from parents to children and increases the risk of many types of cancer , Including colon cancer, endometrial cancer, ovarian kenza, gastric cancer, small intestine cancer, pancreatic cancer, kidney cancer, brain cancer and cholangiocarcinoma. Especially kenza yemaroni and rectal cancer. People with Lynch syndrome have a 70% to 80% risk of colorectal cancer.
MuUnited States, angangoita zana nemakumi mana ezviuru zviitiko zvegomarara rakasarudzika zvinoonekwa gore rega rega. Inenge 140,000% kusvika ku3% yekenza idzi dzinokonzerwa neLynch syndrome.
Mushonga wekudzivirira Lynch syndrome
Parizvino, varwere vane Lynch syndrome vanogona chete kudzivirira colorectal cancer kuburikidza nekuongororwa uye kudzivirira. Low-dose aspirin yakaratidzwawo mumakiriniki ekuedzwa kuderedza njodzi yegomarara remukati.
Uye majekiseni ekudzivirira anogona kupa imwe, inogona kuita nzira inoshanda yekumisa kukura kwekenza.
Munguva pfupi yapfuura, vaongorori vakatora danho rakakosha mukuvandudza majekiseni ekudzivirira chirwere chine njodzi checancer, Lynch syndrome (Lynch).
Masayendisiti anotungamirwa naSteven Cornkin, MD, waWeill Cornell, vakataura zvakabuda pamatanho eNCI-akapihwa mari yekudzivirira chirwere chegomarara pamusangano wepagore weAmerican Association for Cancer Research. Inofananidzwa nemakonzo asina kubviswa, uyu mushonga wakadzivirira kukura kwemamota ane ruvara uye wakawedzera kupona kwemakonzo muLynch syndrome mbeva modhi.
Muongorori mukuru, Dr. Lipkin, uye mutevedzeri wasachigaro wekutsvagisa kuDhipatimendi reMishonga muNew York, anoronga kuzivisa zvakajairika maoantigengen anoitika mumatumbu ekutanga ane mavara muvarwere vane Lynch syndrome. Iyo purojekiti yakapihwa mari neNational Cancer Institute (NCI) kuburikidza neCancer "Moon Exploration Program" immuno-oncology shanduko network.
Dr. Lipkin akataura kuti kana kuyedzwa kwevanhu kwejekiseni rekudzivirira gomarara kukafambira mberi, zvinotora makore akati wandei kuona kana ichishanda.
Panguva imwecheteyo, timu yake iri kushandisa mhando dzemakonzo kuti vanzwisise zvirinani kuti mushonga unoshanda sei uye kuti maseru egomarara ari kukura anorwisa sei zvainoita.
Kuwanikwa kwekuchinja kwakawanda muLynch syndrome kenza
Lynch syndrome inokonzerwa nekuzvarwa nhaka, izvo zvinogona kudzivirira kugadziriswa kweDNA zvikanganiso zvinoitika panguva yekuparadzaniswa kwesero. Mhosho dzakadai dzinodaidzwa kuti mismatch kugadzirisa kukanganisa
Izvi zvakafanana nekusashandisa DNA spell checker. Pasina kuzvidzivirira uku, zvikanganiso zveDNA zvinoungana mumasero uye zvinogona kuzopedzisira zvaunza kanzura dzakasiyana siyana.
Ipfupi inodzokorora zvimedu zveDNA zvinonzi microsatellites zvinonyanya kutarisana neDNA zvisizvo. Mamota ane kusagadzikana kwekugadzirisa anozopedzisira aunganidza shanduko mune aya ma microsatellites. Aya mamiriro anonzi microsatellite kusagadzikana.
Microsatellite isina kugadzikana mamota anogona kuburitsa mapuroteni matsva, anonzi matsva maantigen, zvinova zvinhu zvekunze kumutumbi uye zvinogona kukonzera immune system kurwisa maseru anogadzira aya mapuroteni.
Nekuda kweizvozvo, vaongorori vakawana ruzivo rwakakosha. Mamota akaumbwa muvanhu vane Lynch syndrome anowanzove neiyo microsatellite shanduko, senge mune 60% kusvika 80% yevanhu vane colorectal cancer iyo ine mismatch kugadzirisa kuremara. Pachave nekushandurwa kwema microsatellite mune iyo TGFBR2 geni.
Kuvandudza uye kugadzirisa kweanodzivirira gomarara
Muna 2011, vatsvagiri veNational Cancer Research Center muHeidelberg, Germany, vakatanga kiriniki yekuyedza majekiseni matsva eantigen muvanhu vane gomarara rakakura. Varwere ava vane yakanyanya microsatellite kusagadzikana.
Kutanga, masayendisiti akatsvaga DNA kubva pamakumi matatu nematatu emota anowanikwa muLynch syndrome mbeva modhi uye akaona gumi nematanhatu shanduko.
Vatsvakurudzi vakabva vashandisa algorithm kufanotaura kuti ndedzipi shanduko dzichagovana maantigen, uye pakupedzisira vakazoona mhando gumi. Pavakabairira aya maantigen gumi matsva mumakonzo, mana awo akakonzera kusimba kwekudzivirira immune.
Aya mana maantigenheni matsva akabatanidzwa kugadzira mushonga wembeva. Vakaona kuti kushandiswa kwemishonga yekudzivirira uye adjuvants mune yegonzo modhi yeLynch syndrome inogona kudzikisira kukura kwemavara akajeka uye kuwedzera kurarama.
"Iyi ndeimwe yekenza yekutanga yekudzivirira gomarara inoshandisa maantigen nyowani anogona kuumbwa neDNA mismatch kugadzirisa kukanganisa," akadaro Dr. Umar.
Tevere, vaongorori vakaona kana kubatanidza jekiseni pamwe nemimwe mishonga kunogona kuvandudza kushanda kwayo. Semuenzaniso, Naprosyn, inowanzo shandiswa analgesic, yakaratidzirwa kuve yakakwira kupfuura aspirin kana kudzora mukuderedza kukura kwemamota akasarudzika mumhando dzemakonzo. Naproxen inoita kunge inowedzera kushanda kwejekiseni. Mbeva dzakarapwa nemushonga pamwe naproxen dzakararama kwenguva yakareba kupfuura mbeva dzakabayiwa dzoga kana kubayiwa pamwe nemaaspirin Masero emumuviri ekudzivirira pamwe neboka re naproxen akakwanisa kuona mushonga mutsva antigen kupfuura mbeva dziri mujekiseni chete kana jekiseni pamwe neboka reasipurini.
mhedziso
Vanhu vane Lynch syndrome vanozove vanokwikwidza majekiseni ekudzivirira gomarara, Kana akagadzirwa.
Nhungamiro yeNCCN yazvino inokurudzira microsatellite kusagadzikana kuyedza kune vanhu vane colorectal cancer uye endometrial cancer. Kana bundu remurwere riine kusagadzikana kwemicrosatellite, zvinokurudzirwa kuti riongororwe chirwere cheLynch. Kana ikaonekwa seLynch syndrome, zvinokurudzirwa kuedza hama dzekutanga dzemurwere kudzivirira kuti zvirege kuitika.
Zvinokurudzirwa kuti mapoka ane njodzi huru anogona kuongororwa majini ekubatwa nemagene. Kune mamwe marudzi ekuongorora, ndokumbira ubvunze Global Oncologist Network Medical Dhipatimendi (400-666-7998), uye sarudza zvichibva pane yako nhoroondo yemhuri uye njodzi zvinhu
- Kenza majini anokonzeresa kuwanikwa kwejini (huwandu hwese 139 magene):
- Inovhara makumi mapfumbamwe nemakumi mana nematanhatu mumagenome ehunhu ane hukama negomarara, inosanganisira makumi maviri marudzi ekenza uye makumi manomwe emhando dzegomarara-zvine hukama nemagene syndromes
- Tumor genetic susceptibility gene test (23 geni rakajairika):
- Inosanganisira 8 mhando dzekenza ine njodzi huru uye gumi nemana marudzi eanowanzoitika majini syndromes
- Kenza genitusinowanikwa geni bvunzo (18 mageneti evakadzi):
- Inosanganisira matatu marudzi emota ane njodzi huru uye marudzi mashanu ehukama hwemagene syndromes
- Kenza majini anokonzeresa kuwanikwa kwejini (gumi nemanomwe majini ari mudumbu):
- Inosanganisira mashanu marudzi eakanyanya-njodzi ekugaya matumbu mapundu uye masere marudzi eanoenderana nemagene syndromes
- Kansa yepabonde + breast cancer: BRCA1 / 2 gene
- Colorectal cancer: 17 majeni
- Mamota ese: mageneti makumi mana nemana
