Mushonga unoshandiswa pakudhakwa unogona kurapa cancer nekunanga macrophages
Boka rekutsvagisa rinotungamirwa naYuya Terashima kubva kuTokyo University rakaona kuti mushonga unoshandiswa pakudhakwa unogona kurapa kenza nekunangisa macrophages.
Sekureva kweWHO uye International Agency for Research on Cancer (IARC) data, pakanga paine 18.1 miriyoni zviitiko zvitsva uye 9.6 miriyoni vakafa muna 2018. Mumwe muvarume 5 uye mumwe chete pavakadzi 6 pasi rose vanova nekenza munguva yehupenyu hwavo, uye mumwe muvarume 8 uye mumwe chete pavakadzi gumi nemumwe vanofa nechirwere ichi. Pasi rose, huwandu hwevanhu vari kurarama mukati memakore mashanu echirwere chegomarara, inonzi 11-year prevalence, inofungidzirwa kuva 5 miriyoni.
Kanza yemaperembudzi imhando yegomarara rinonyanya kuwanda muvarume (14.5%) uye iri kukonzera rufu muvarume (22%). Izvi zvinoteverwa ne Kenza yeprotate (13.5%) , kenza yakajeka (10.9%), & gomarara rechiropa (9.5%). Pakati pevakadzi, kenza yebonde ingangoita 25%, ichiteverwa nekenza yemapapu (13.8%), colorectal cancer (9.5%), & cervical cancer (6.6%).
Kuvaka a kurapwa kurwisa zvinouraya kukura kunoramba kuri chimwe chezvinetso zvinonetsa mukutsvakurudza kwemishonga. Kukura kwakashata kunokwereta hunhu hwayo husina kunaka nenzira iyo masero echirwere anoshandisa iyo inodzivirira chimiro cheanotambira kuti akudziridze nekupararira, pakupedzisira ave nehutsinye. Maseru asingapindike senge macrophages, ayo anowanzo kurwisa kuti ave nechokwadi masero, anodzorwa nemasero ane njodzi echirwere, uye anozadza pasi pakatenderedza mapundu, achizove macrophages ane hukama nebundu (TAMs).
Chaizvoizvo, zvakaonekwa kuti huturu hwevarwere vaani immunotherapy yakanga isina kubereka yakanga yakapfuma mune macrophages, ichisimbisa kubatana pakati pechirwere neTAMs. Ndiwo maTAM aya anoburitsa mapuroteni emuchadenga senge chemokines uye anokonzeresa inhibitory resistant checkpoint discharges izvo zvinoita immunosuppressive. tumarara mamiriro, ayo anovimbisa kukura kwakashata masero uye anobvumira kukurumidza kukura kwavo. Sezvo maTAM anokurudzira kupararira kwezvakaipa kukura masero, kuagadzirisa senzira yekugadzirisa kurwisa chirwere kwave kutariswa semazuvano.
Boka rekutsvagisa kubva kuTokyo University yeScience, riri pasi pekutungamirwa naYuya Terashima rakaona uyu semukana wekutarisa mumunda wekugadzira mishonga mitsva inopesana nekukura. Basa ravo rekutanga muNature Immunology 2005 rakaburitsa kuburitswa kweimwe chinangwa cheprotein inonzi FROUNT, iyo yakabatana negwara uye kusimudzira kweTAM. Nenzira iyi, FROUNT yakabatana zvakananga nemitemo yeTAM nokuti yakawedzera "chemokine signing," rudzi rwekutaurirana kwesero kunodiwa kuTAM kuunganidza uye kufamba.
Panguva iyoyo, kuti kuderedze chero zviratidzo, boka rakagadzirawo nzira yekuzvimiririra yekudzora maitiro eFROUNT pane chemokine kufamba nekudzvanyirira kubatana pakati pezviviri izvi. Boka rakaongorora 131,200 misanganiswa uye yakanangana nedisulfiram, mushonga unoshandiswa kurapa kudhakwa kwedoro, uye inotaurwa nezvayo kugona kwayo semuvengi weanokuvadza kukura kwerunyararo. Mushonga uyu wakawanikwa uchisunga zviri pamutemo kune FROUNT saiti, zvichiita kuti FROUNT isasvike pakubatana nezvikamu zve chemokine mureza.
Achifunga nezvemhedzisiro, Terashima anotsanangura, "Payakaedzwa pamakonzo, disulfiram yakadzora kukura kwema macrophages uye yakamisa kukura kwemasero anokuvadza ekukura. Nekudaro, zvatakawana zvinoburitsa nzira nyowani yekurapa cancer inogona kumisa kukura kwemaseru egomarara ayo akaomarara kuti immune system ione kana ikashandiswa pamwe chete nedisulfiram.
Ndinovimba, tichasvika pakuona zvitsva marapiro mukurapa kenza.
