Huwandu hwekupona kwegomarara repancreatic hwakadzikira. Mumakore makumi mana apfuura, mwero wekupona hauna kuchinja zvakanyanya. Kuwana marapirwo anobudirira idambudziko rekukurumidzira kune vaongorori. Kwemakore akawanda, tamoxifen yave ichishandiswa kurapa kenza yemazamu nekuti inhibits estrogen kukurudzira bundu rezamu. Munguva pfupi yapfuura, zvidzidzo zvakaratidza kuti tamoxifen inogona kushandiswa kurapa gomarara repancreatic. Chikwata chekutsvagisa chakaratidza kuti tamoxifen inogona kubatsira kushandura nharaunda yembeva bundu kukura, kudzora mavanga ekukura kwetishu, kuzvimba uye mhinduro yekudzivirira. Mhedzisiro yetsvagiridzo inoburitswa mu "EMBO Report".
Pancreatic cancer, like most solid tumors, is surrounded by a large amount of connective tissue. The stiff scar-like tissues are like scaffolding around tumors. They block the delivery of drugs by preventing chemotherapy drugs from reaching the tumor. They also regulate the growth and spread of tumors. Iko kuumbwa kweanobatanidza matissue mupancreatic tumors inotungamirwa nepancreatic stellate maseru (PSCs), ayo anosimbiswa nekushandiswa kwesimba remuviri uye kugadzirisa kwechimiro chemuviri.
Vatsvagiri pavakadzidza mbeva pancreatic tumor modhi, vakawana kudyidzana pakati pemasero akatenderedza pancreatic bundu, uye vakadzidzawo kuti tamoxifen yakachinja sei nharaunda yemuviri yakatenderedza pancreatic bundu. Tamoxifen inokwanisa kuvharidzira matishu akabatana akatenderedza PSC sclerosis tumors uye kudzivirira nharaunda yakatenderedza kubva pakuoma. Tamoxifen inogadzirisa maitiro ezvirwere zvemuviri uye inogona kuvharidzira kupinda uye kupararira kwekenza masero. Uyezve, maseru ari mupancreatic bundu anoratidzwa kune shoma shoma, iyo inogadzira nzira yekudzivirira: kana mwero weokisijeni wadonha, sero rinoburitsa molekuru inonzi hypoxia inducible factor (HIF), iyo inobatsira cancer maseru Kupona mumamiriro ezvinhu. Asi tamoxifen inogona kutadzisa kugadzirwa kweHIF, ichiita kuti masero egomarara atarisike kune yakaderera oksijeni mwero uye anogona kufa. Asi basa iri parizvino ririkuitwa pamasero tsika nembeva modhi, saka tsvakiridzo yakawanda inodiwa isati yashandiswa kuvarwere vevanhu.
