Mingyang Song iz medicinske šole Harvard in splošne bolnišnice Massachusetts so poročali, da bo po diagnozi nemetastatskega raka debelega črevesa in danke zaužitje več vlaknin zmanjšalo specifično smrtnost in splošno smrtnost raka debelega črevesa in danke. Povečanje vnosa vlaknin po diagnozi lahko koristi bolnikom s kolorektalnim rakom. (JAMA Oncol. Spletna različica 2. novembra 2017).
Although it has been shown that high dietary fiber intake reduces the risk of colorectal cancer, it is not clear whether high fiber intake will benefit colorectal preživele raka.
Da bi ocenili razmerje med vnosom vlaknin in smrtnostjo, je študija vključila 1575 bolnikov s kolorektalnim rakom od I do III iz dveh potencialnih kohort; po prilagoditvi za druge potencialne napovedovalce preživetja raka je bila določena specifičnost kolorektalnega raka Smrtnost in skupna umrljivost.
Med 6 meseci in 4 leti po diagnozi raka debelega črevesa in danke so raziskovalci s potrjenim vprašalnikom o pogostosti prehranjevanja ocenili skupni vnos vlaknin, količino vlaknin iz različnih virov in količino polnozrnate pšenice.
Among the 1575 participants, 963 (61.1%) were women; the average age was 68.6 years. With a median follow-up of 8 years, 773 patients died, of which 174 died from colorectal cancer. A high total fiber intake after diagnosis is associated with a lower mortality rate. For every 5g increase in daily intake, the multivariable HR for colorectal cancer specific mortality and all-cause mortality were 0.78 (95% CI 0.65 ~ 0.93; P = 0.006) and 0.86 (95% CI 0.79 ~ 0.93) P <0 .001). According to fiber sources, cereal fiber can reduce debelega črevesa in danke cancer-specific mortality (for every 5 g / d increase in intake, HR = 0.67, 95% CI 0.50 ~ 0.90; P = 0.007) and all-cause mortality (HR = 0.78, 95% CI 0.68 ~ 0.90; P <0.001); vegetable fiber can reduce all-cause mortality (HR = 0.83, 95% CI 0.72 ~ 0.96; P = 0.009), but it does not reduce colorectal cancer-specific mortality (HR = 0.82, 95% CI 0.60 ~ 1.13; P = 0.22); No correlation was found between fruit fiber and mortality. Ingestion of whole wheat food can reduce the specific mortality of colorectal cancer (for every 20 g / d increase in intake, HR = 0.72, 95% CI 0.59 ~ 0.88; P = 0.002), but the correlation It will weaken after entry (HR = 0.77, 95% CI 0.62 ~ 0.96; P = 0.02).
