Dr. Edwin P. Alyea

Edwin P. Alyea je specializiran za zdravljenje bolnikov s krvnim rakom, ki razmišljajo o presaditvi matičnih celic ali kostnega mozga. V zadnjih 20 letih je prišlo do bistvenega napredka na področju transplantacije, kar je prineslo boljše rezultate. Ta napredek vključuje zmožnost uporabe nižjih odmerkov kemoterapije za zmanjšanje toksičnosti pri bolnikih, pa tudi metode za zmanjšanje verjetnosti ponovitve. Zanima me uporaba novih zdravil in tehnik za izboljšanje rezultatov po presaditvi matičnih celic za maligne bolezni krvi. Ključnega pomena je sodelovanje z bolniki, da se določijo njihovi cilji zdravljenja in najboljši način ukrepanja. Že vrsto let po njihovi presaditvi sem rad delal z bolniki in njihovimi družinami.

Certifikat odbora

American Board of Internal Med, Medical Oncology

Fellowship

Medicinska onkologija, Inštitut za raka Dana-Farber (Massachusetts), 1992-1995

Prebivališče

Interna medicina, Brigham and Women's Hospital (Massachusetts), 1989-1992

Izobraževanje

MD, Univerza Duke, 1989

• Transplantacija odraslega kostnega mozga in izvornih celic
• Avtologna presaditev
• Alogenska presaditev
• Singenska presaditev

• Hourigan, Christopher S., Laura W. Dillon, Gege Gui, Brent R. Logan, Mingwei Fei, Jack Ghannam, Yuesheng Li, et al. “Impact of Conditioning Intensity of Allogeneic Transplantation for Akutna mieloidna levkemija With Genomic Evidence of Residual Disease.” J Clin Oncol 38, št. 12 (20. april 2020): 1273–83. https://doi.org/10.1200/JCO.19.03011.
• Soiffer, Robert J., Haesook T. Kim, Joseph McGuirk, Mitchell E. Horwitz, Laura Johnston, Mrinal M. Patnaik, Witold Rybka, et al. “Prospective, Randomized, Double-Blind, Phase III Clinical Trial of Anti-T-Lymphocyte Globulin to Assess Impact on Chronic Graft-Versus-Host Disease-Free Survival in Patients Undergoing HLA-Matched Unrelated Myeloablative Hematopoietic Cell Transplantation.” J Clin Oncol 35, št. 36 (20. december 2017): 4003–11. https://doi.org/10.1200/JCO.2017.75.8177.
• Liu, Hien Duong, Kwang Woo Ahn, Zhen-Huan Hu, Mehdi Hamadani, Taiga Nishihori, Baldeep Wirk, Amer Beitinjaneh, et al. “Allogeneic Hematopoietic Cell Transplantation for Adult Chronic Myelomonocytic Leukemia.” Biol presaditev krvnega mozga 23, št. 5 (maj 2017): 767–75. https://doi.org/10.1016/j.bbmt.2017.01.078.
• Scott, Bart L., Marcelo C. Pasquini, Brent R. Logan, Juan Wu, Steven M. Devine, David L. Porter, Richard T. Maziarz, et al. “Myeloablative Versus Reduced-Intensity Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndromes.” J Clin Oncol 35, št. 11 (10. april 2017): 1154–61. https://doi.org/10.1200/JCO.2016.70.7091.
• Shaffer, Brian C., Kwang Woo Ahn, Zhen-Huan Hu, Taiga Nishihori, Adriana K. Malone, David Valcárcel, Michael R. Grunwald, et al. “Scoring System Prognostic of Outcome in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndrome.” J Clin Oncol 34, št. 16 (1. junij 2016): 1864–71. https://doi.org/10.1200/JCO.2015.65.0515.
• Devine, Steven M., Kouros Owzar, William Blum, Flora Mulkey, Richard M. Stone, Jack W. Hsu, Richard E. Champlin, et al. “Phase II Study of Allogeneic Transplantation for Older Patients With Acute Myeloid Leukemia in First Complete Remission Using a Reduced-Intensity Conditioning Regimen: Results From Cancer and Leukemia Group B 100103 (Alliance for Clinical Trials in Oncology)/Blood and Marrow Transplant Clinical Trial Network 0502.” J Clin Oncol 33, št. 35 (10. december 2015): 4167–75. https://doi.org/10.1200/JCO.2015.62.7273.
• Jacobson, Caron A., Lixian Sun, Haesook T. Kim, Sean M. McDonough, Carol G. Reynolds, Michael Schowalter, John Koreth, et al. “Post-transplantation B cell activating factor and B cell recovery before onset of chronic graft-versus-host disease.” Biol presaditev krvnega mozga 20, št. 5 (maj 2014): 668–75. https://doi.org/10.1016/j.bbmt.2014.01.021.
• Cutler, Corey, Haesook T. Kim, Bhavjot Bindra, Stefanie Sarantopoulos, Vincent T. Ho, Yi-Bin Chen, Jacalyn Rosenblatt, et al. “Rituximab prophylaxis prevents corticosteroid-requiring chronic GVHD after allogeneic peripheral blood stem cell transplantation: results of a phase 2 trial.” Blood 122, št. 8 (22. avgust 2013): 1510–17. https://doi.org/10.1182/blood-2013-04-495895.
• Porcheray, Fabrice, David B. Miklos, Blair H. Floyd, Stefanie Sarantopoulos, Roberto Bellucci, Robert J. Soiffer, Joseph H. Antin, Edwin P. Alyea, Jerome Ritz, and Emmanuel Zorn. “Combined CD4 T-cell and antibody response to human minor histocompatibility antigen DBY after allogeneic stem-cell transplantation.” Presaditev 92, št. 3 (15. avgust 2011): 359–65. https://doi.org/10.1097/TP.0b013e3182244cc3.