Лекарство от алкоголизма может лечить рак, воздействуя на макрофаги
Исследовательская группа под руководством Юи Терашимы из Токийского университета обнаружила, что препарат, используемый при алкоголизме, может лечить Онкология путем воздействия на макрофаги.
По данным ВОЗ и Международного агентства по исследованию рака (IARC), в 18.1 году было зарегистрировано 9.6 миллиона новых случаев заболевания и 2018 миллиона смертей. Каждый пятый мужчина и каждая шестая женщина в мире заболевают раком в течение жизни, а каждый восьмой мужчина и женщина одна из 5 женщин умирает от этой болезни. Во всем мире общее число людей, живущих в течение 6 лет после постановки диагноза рака, называемое 8-летней распространенностью, оценивается в 11 миллиона человек.
Рак легких является наиболее распространенным типом рака у мужчин (14.5%) и основной причиной смертности мужчин (22%). За этим следует рак предстательной железы (13.5%), колоректальный рак (10.9%), & рак печени (9.5%). Среди женщин, рак молочной железы составляет примерно 25%, за ним следуют рак легких (13.8%), колоректальный рак (9.5%) и рак шейки матки (6.6%).
Building up a treatment to battle malignant growth remains one of the most troublesome difficulties in medicinal research. Malignant growth owes its infamous personality to the way that the disease cells utilize the host’s own resistant framework to develop and spread, finally getting savage. Invulnerable cells like macrophages, which usually battle to ensure ordinary cells, are commandeered by dangerous disease cells, and populate the earth around the tumors, turning out to be tumor-related macrophages (TAMs).
Actually, it was discovered that the malignant tissue of patients for whom иммунотерапия was not fruitful was in fact rich in macrophages, affirming the connection between the disease and the TAMs. It is these TAMs that produce flagging proteins like chemokines and trigger the inhibitory resistant checkpoint discharges that make an immunosuppressive опухоль condition, which ensures the malignant growth cells and permits their quickened development. Since the TAMs encourage the spreading of malignant клетки роста, managing them as a remedial methodology for battling disease has picked up consideration as of late.
A research team from the Tokyo University of Science, under the direction of Yuya Terashima saw this as an opportunity to look into the field of developing new anti-malignant growth drugs. Their original work in Nature Immunology 2005 revealed the disclosure of another objective protein called FROUNT, which is connected to the guidelines and development of the TAMs. In this way, FROUNT was directly linked to TAM rules because it increased “chemokine signaling,” a type of cell communication that is necessary for TAM gathering and movement.
At that point, so as to diminish any symptoms, the group additionally built up an autonomous technique for restricting the impact of FROUNT on chemokine motion by repressing the connection between the two. The group screened 131,200 mixes and focused on disulfiram, a medication used to treat liquor abuse, and referred to for its potential as an enemy of malignant growth tranquilizer. This medication was found to legitimately tie to the FROUNT site, making FROUNT inaccessible for collaboration with the parts of chemokine flagging.
Considering the outcomes, Terashima clarifies, “When tried on mice, disulfiram repressed the development of macrophages and stifled the development of malignant growth cells. Thus, our findings reveal a new way to treat cancer that can stop the growth of cancer cells that are hard for immune systems to detect when used together with disulfiram.
Hopefully, we will get to see new therapies in the treatment of cancer.
