Britse wetenschappers beginnen met het genetisch testen van kindertumoren. Britse wetenschappers hopen dat genetische tests jongere patiënten nieuwere en meer gepersonaliseerde behandelingen zullen geven die hun overleving zullen vergroten. De nieuwe test analyseert 81 verschillende genetische veranderingen bij kanker.
Scientists say the test will lead to “a higher level of playing field” and accelerate children’s access to important new drug treatments. The test was performed at the Royal Marsden National Health System Hospital in London and will be tested on 400 children from all over the UK over the next two years.
The test has been implemented with genetic funding from the National Institutes of Health (NIHR) foundation and the Kanker Institute. A charity called Christopher has provided more than £ 300,000 in funding to develop the test. The organization was founded by a couple whose children died of invasive hersentumors op de leeftijd van zes jaar.
This is a real first step towards personalized kankerbehandeling for children,” said Christopher’s parents, Karen and Kevin Capel. Christopher got a generic tumor. Hopefully, in the future, children will know exactly what type of tumor they have.” “We almost feel that the treatment for the child is not to kill the cancer, but to kill our child.”
“He used to be a healthy, happy, very athletic 4-year-old kid. But he became unable to speak or even eat on his own, and lost weight. “In the year he was diagnosed, he was unable to grow into a child of his age. We tried to keep him from other children.”
Kwaadaardige tumoren zijn zeer zeldzaam bij kinderen, er zijn niet veel patiëntenpopulaties, en klinische proeven for pharmaceutical companies will lack motivation. This means that children will miss the opportunity to receive targeted treatments for cancer cells without damaging healthy cells with innovative therapies.
Professor Louis Chesler, who is leading the genetic testing research, said: “Children often don’t have equal access to the most advanced and potentially beneficial cancer treatments.” “The cost of developing gene-targeted drugs is very high. They tend to Test it on adults first so that more people can get treatment and the results can be seen faster. ”
"Deze test is een ongelooflijke vooruitgang omdat hij alle genetische veranderingen in de tumor heel duidelijk zal identificeren." “Gentesten geven clinici een buitengewoon krachtig hulpmiddel: ze helpen het juiste medicijn voor hun kinderen te kiezen en hun best te doen. Het is wellicht mogelijk om snel de effectiviteit van deze medicijnen te bepalen. "
Children’s tumors are usually genetically simpler than adult tumors, so eventually these drugs may be more effective in children.” The goal of genetische test is to give scientists and doctors detailed genes for childhood tumors within a few weeks of diagnosis. information.
Genetic testing gives doctors strong evidence to use gerichte therapieën for younger patients, potentially preventing these patients from experiencing the side effects associated with traditional chemotherapy and radiation therapy.
Jack Daly, 14, from Wokingham, was diagnosed with a brain tumor when he was 7 and is now a brain tumor overlevende. Radiotherapy helped save his life, but left him with sequelae. “My athletic ability is not very good,” Jack said. “I have to get someone to help me dress and undress at school.” “My balance is not good-I am awkward and often fall. I worked hard at school, where I found friendship.” Jack and his mother, Helen, use their donations to make ends meet in Capels-hoping that genetische test will make a huge difference in the quality of life of future children.
'Mensen zien het probleem niet echt in, omdat Jack is hersteld van kanker. Hij hoeft niet in een rolstoel te zitten. Hij hoeft geen verband te dragen, 'zei Helen.
'Als je Jack ooit hebt gezien, hij ziet eruit als een normale tienerjongen. Maar wat je niet ziet, is de schade aan het hersenweefsel die door de behandeling wordt veroorzaakt. "
Bron-URL van dit artikel: http://www.bbc.com/news/health-35918744
