Mingyang Song van de Harvard Medical School en het Massachusetts General Hospital rapporteerden dat na de diagnose van niet-uitgezaaide colorectale kanker, de inname van meer vezels de specifieke mortaliteit en de algehele mortaliteit van colorectale kanker zal verminderen. Het verhogen van de vezelinname na de diagnose kan patiënten met darmkanker ten goede komen. (JAMA Oncol. Online versie op 2 november 2017).
Although it has been shown that high dietary fiber intake reduces the risk of colorectal cancer, it is not clear whether high fiber intake will benefit colorectal kanker overlevenden.
Om de relatie tussen vezelinname en mortaliteit te beoordelen, omvatte de studie 1575 patiënten met stadium I tot III colorectale kanker uit twee prospectieve cohorten; na correctie voor andere mogelijke voorspellers van kankeroverleving werd de specificiteit van colorectale kanker bepaald. Sterfte en totale mortaliteit.
Tussen 6 maanden en 4 jaar na de diagnose darmkanker gebruikten de onderzoekers een gevalideerde vragenlijst over de eetfrequentie om de totale vezelinname, de hoeveelheid vezels uit verschillende bronnen en de hoeveelheid volkoren tarwe te beoordelen.
Among the 1575 participants, 963 (61.1%) were women; the average age was 68.6 years. With a median follow-up of 8 years, 773 patients died, of which 174 died from colorectal cancer. A high total fiber intake after diagnosis is associated with a lower mortality rate. For every 5g increase in daily intake, the multivariable HR for colorectal cancer specific mortality and all-cause mortality were 0.78 (95% CI 0.65 ~ 0.93; P = 0.006) and 0.86 (95% CI 0.79 ~ 0.93) P <0 .001). According to fiber sources, cereal fiber can reduce colorectale cancer-specific mortality (for every 5 g / d increase in intake, HR = 0.67, 95% CI 0.50 ~ 0.90; P = 0.007) and all-cause mortality (HR = 0.78, 95% CI 0.68 ~ 0.90; P <0.001); vegetable fiber can reduce all-cause mortality (HR = 0.83, 95% CI 0.72 ~ 0.96; P = 0.009), but it does not reduce colorectal cancer-specific mortality (HR = 0.82, 95% CI 0.60 ~ 1.13; P = 0.22); No correlation was found between fruit fiber and mortality. Ingestion of whole wheat food can reduce the specific mortality of colorectal cancer (for every 20 g / d increase in intake, HR = 0.72, 95% CI 0.59 ~ 0.88; P = 0.002), but the correlation It will weaken after entry (HR = 0.77, 95% CI 0.62 ~ 0.96; P = 0.02).
