Mingyang Song dari Sekolah Perubatan Harvard dan Hospital Besar Massachusetts melaporkan bahawa selepas diagnosis kanser kolorektal bukan metastatik, pengambilan lebih banyak serat akan mengurangkan kematian spesifik dan kematian keseluruhan kanser kolorektal. Peningkatan pengambilan serat selepas diagnosis dapat memberi manfaat kepada pesakit dengan barah kolorektal. (JAMA Oncol. Versi dalam talian pada 2 November 2017).
Although it has been shown that high dietary fiber intake reduces the risk of colorectal cancer, it is not clear whether high fiber intake will benefit colorectal mangsa barah.
Untuk menilai hubungan antara pengambilan serat dan kematian, kajian ini melibatkan 1575 pesakit dengan barah kolorektal tahap I hingga III dari dua calon kohort; setelah menyesuaikan dengan ramalan kelangsungan hidup kanser yang berpotensi lain, kekhususan kanser kolorektal ditentukan Kematian dan kematian total.
Antara 6 bulan dan 4 tahun setelah diagnosis barah kolorektal, para penyelidik menggunakan soal selidik yang disahkan mengenai kekerapan makan untuk menilai jumlah pengambilan serat, jumlah serat dari sumber yang berlainan dan jumlah gandum.
Among the 1575 participants, 963 (61.1%) were women; the average age was 68.6 years. With a median follow-up of 8 years, 773 patients died, of which 174 died from colorectal cancer. A high total fiber intake after diagnosis is associated with a lower mortality rate. For every 5g increase in daily intake, the multivariable HR for colorectal cancer specific mortality and all-cause mortality were 0.78 (95% CI 0.65 ~ 0.93; P = 0.006) and 0.86 (95% CI 0.79 ~ 0.93) P <0 .001). According to fiber sources, cereal fiber can reduce kolorektal cancer-specific mortality (for every 5 g / d increase in intake, HR = 0.67, 95% CI 0.50 ~ 0.90; P = 0.007) and all-cause mortality (HR = 0.78, 95% CI 0.68 ~ 0.90; P <0.001); vegetable fiber can reduce all-cause mortality (HR = 0.83, 95% CI 0.72 ~ 0.96; P = 0.009), but it does not reduce colorectal cancer-specific mortality (HR = 0.82, 95% CI 0.60 ~ 1.13; P = 0.22); No correlation was found between fruit fiber and mortality. Ingestion of whole wheat food can reduce the specific mortality of colorectal cancer (for every 20 g / d increase in intake, HR = 0.72, 95% CI 0.59 ~ 0.88; P = 0.002), but the correlation It will weaken after entry (HR = 0.77, 95% CI 0.62 ~ 0.96; P = 0.02).
