Iecoris cancer, quod habet multas species; hæreditatem fortis et facile accessit, demonstrando biomarkers qui dicunt morbo est a key propositum progressum iecoris cancer in pugnam.
Nuper, ego developed per modum inquisitores ut identify communis forma maxime iecoris cancer-hepatocellular carcinoma (HCC) secundum splicing biomarkers. Et credunt quod modum adhiberi possunt etiam alia genera cancer. Hoc studium effert quomodo RNA splicing alte cadere contribuere ad cancer, et illa puncta sicco ut alte cadere potest progressum potentiales biomarkers ad cancer.
Splicing refers to a processus in qua RNA copied notitia ex notitia edidit ante encoded in gene est non potest esse propria, ut in tabula dapibus. A gene potest producere et RNA monita atque inter se variant nuntius fit alius dapibus vel "isomer". Multa sunt ad morbo aut variationes in RNA splicing modi errorum. Quos errores consequuntur seu mutationes in splicing potest in alia proteins, cum alius aut munera.
Recent research has identified splicing irregularities in iecoris cancer cells. Krainer’s team has developed a method that can comprehensively analyze all RNA information produced by a given gene. The team tested their methods of detecting splice variants in HCC by analyzing RNA information from HCC cells collected from hundreds of patients.
They found that the specific splicing isoform of the AFMID gene is associated with the patient’s low survival. These variants result in cells making truncated versions of the AFMID protein. These unusual proteins are associated with mutations in TP53 and ARID1A tuberculum suppressor genes in adult liver cancer cells.
Investigatores hypothesaverunt has mutationes referuntur ad imum gradum moleculi nomine NAD +, quod involvit in reparatione laesa DNA. Reparans AFMID plicatio auctam NAD + productionem ducere potest et DNA augeri. Si hoc facere possumus, AFMID sutura scopum medicinale fieri potest et fons novarum medicamentorum cancri hepatis. Praevia experimenta ostendunt investigationem bigam esse in vestigio recto, et exspectamus meliores notitias eventus ut aegros cancer iecoris prodesset.
