Inflammatio chronica est praeses elementum cancri colorectalis, quae tertia causa ducens mortem cancri in Civitatibus Foederatis relatas est. Dr. Anna Means et collegae in ephemeride Cell et Molecular Gastroenterologiam et Hepatologiam mense ultimo retulerunt se carcinogenesis coloniae inflammationem agitatam ad amissionem dapibus magni significationis vocati SMAD4. SMAD4 pars est factoris incrementi β (TGF-β) significantem viam, quae responsionem immunem et inflammationem regit ad infectionem epithelii colonici.
Et specifica per normalis mus colonia deletionem SMAD4 gene expressio inflammatione mediatores, auxerat epithelial cellulis in vivo crevit. In adulta habebat mures aureos et frigore, ardore et indigentiam SMAD4 results habita mirum in secretiori parte natium similem esse consociata et carcinomata apud hominem colitis.
Loss of SMAD4 was also observed in 48% of human colitis-related cancers, compared with 19% of scattered colorectal cancer. “This loss may be an important factor from premalignant lesions to aggressive malignant tumors,” the researchers concluded. Therefore, friends with chronic inflammation must eliminate inflammation in time, and do not regret it until the inflammation develops into cancer.
