Mingyang Song dari Harvard Medical School dan Rumah Sakit Umum Massachusetts melaporkan bahwa setelah diagnosis kanker kolorektal non-metastatik, mengonsumsi lebih banyak serat akan mengurangi angka kematian spesifik dan angka kematian keseluruhan akibat kanker kolorektal. Meningkatkan asupan serat setelah diagnosis dapat bermanfaat bagi pasien kanker kolorektal. (JAMA Oncol. Versi online pada 2 November 2017).
Although it has been shown that high dietary fiber intake reduces the risk of colorectal cancer, it is not clear whether high fiber intake will benefit colorectal penderita kanker.
Untuk menilai hubungan antara asupan serat dan kematian, penelitian ini melibatkan 1575 pasien dengan kanker kolorektal stadium I hingga III dari dua kelompok prospektif; setelah menyesuaikan dengan prediktor kelangsungan hidup kanker potensial lainnya, spesifisitas kanker kolorektal ditentukan Kematian dan kematian total.
Antara 6 bulan dan 4 tahun setelah diagnosis kanker kolorektal, para peneliti menggunakan kuesioner yang divalidasi tentang frekuensi makan untuk menilai total asupan serat, jumlah serat dari berbagai sumber dan jumlah gandum utuh.
Among the 1575 participants, 963 (61.1%) were women; the average age was 68.6 years. With a median follow-up of 8 years, 773 patients died, of which 174 died from colorectal cancer. A high total fiber intake after diagnosis is associated with a lower mortality rate. For every 5g increase in daily intake, the multivariable HR for colorectal cancer specific mortality and all-cause mortality were 0.78 (95% CI 0.65 ~ 0.93; P = 0.006) and 0.86 (95% CI 0.79 ~ 0.93) P <0 .001). According to fiber sources, cereal fiber can reduce kolorektal cancer-specific mortality (for every 5 g / d increase in intake, HR = 0.67, 95% CI 0.50 ~ 0.90; P = 0.007) and all-cause mortality (HR = 0.78, 95% CI 0.68 ~ 0.90; P <0.001); vegetable fiber can reduce all-cause mortality (HR = 0.83, 95% CI 0.72 ~ 0.96; P = 0.009), but it does not reduce colorectal cancer-specific mortality (HR = 0.82, 95% CI 0.60 ~ 1.13; P = 0.22); No correlation was found between fruit fiber and mortality. Ingestion of whole wheat food can reduce the specific mortality of colorectal cancer (for every 20 g / d increase in intake, HR = 0.72, 95% CI 0.59 ~ 0.88; P = 0.002), but the correlation It will weaken after entry (HR = 0.77, 95% CI 0.62 ~ 0.96; P = 0.02).
