Genetsko ispitivanje karcinoma želuca
After nearly ten years of development, tumor genetic testing has become the immediate need of a large number of cancer patients. The test report guidance provided by tumor genetic testing perfectly fits the development concept of precision medicine, and has penetrated into all aspects of the diagnosis and treatment of tumor patients. For patients, they can choose targeted drugs for precise treatment, avoid detours, and avoid unnecessary side effects. bitter.
Trenutno stanje ciljane terapije za rak želuca
In most cases, surgery is still the main treatment for gastric cancer. However, the heterogeneity of gastric cancer is very strong, and its biological behavior is affected by the huge gene regulation in the cell. Therefore, only by classifying the essential characteristics of gastric cancer from the molecular level can early diagnosis and prognosis judgment of the tumor be more reasonable and accurate , Application of molecular targeted drugs for individualized and precise treatment of patients.
Trenutno su odobreni sljedeći ciljani lijekovi:
| Serijski broj | Meta | droga |
| 1 | HER2 | Trastuzumab (Trastuzumab, Herceptin) |
| 2 | VEGFR | Ramucirumab |
| 3 | NTRK | Larotrektinib (LOXO-101) |
| 4 | PD-1 | Pembrolizumab (K drug) |
| 5 | VEGFR-2 | Apatinib (Apatinib, Aitan) |
In addition, there are many other targeted drugs related to gastric cancer in clinical trials, such as drugs that block HER2: lapatinib (Tykerb ®), pertuzumab (Perjeta ®) and trastuzumab emtansine (Kadcyla ®). Drugs that block EGFR: Panitumumab (Victibi®) is a drug that targets EGFR that is being tested for gastric cancer.
The Global Oncologist Network reminds everyone that genetic testing is required before targeted therapy . Only by understanding the type of tumor gene mutation can a reasonable treatment plan be developed to benefit patients. In addition, in the selection of genetic testing technology, it is necessary to select the appropriate testing technology according to its corresponding target . Only by choosing products approved by the State Food and Drug Administration can the accuracy and reliability of the test results be guaranteed.
Kako pacijenti s rakom želuca biraju genetsko testiranje?
The Global Oncologist Network reminds patients that cancer genetic testing and clinical treatment analysis are a systematic project that requires strong laboratory support, high-standard testing quality control and a high-level data analysis team. A good genetic test analysis can avoid the loss of treatment opportunities and save the lives of cancer patients. At present, there are dozens of genetic testing institutions on the market, and patients must carefully select genetic testing companies to ensure the accuracy of the test results.
Ovdje je tehnologija genetskog ispitivanja koju je odobrila FDA!
FoundationOne®CDx
FoundationOne®CDx odobrila je FDA kao prvi prateći dijagnostički proizvod tipa pan-tumora . As a research tool, it assisted the discovery of countless scientific research results, and accumulated a large amount of data during this period. The current test coverage includes 324 genes and two molecular markers (MSI / TMB) that can predict the efficacy of immune checkpoint inhibitors. It can cover all solid tumors (except sarkom) and can directly correspond to 17 ciljane terapije koje je odobrila FDA!
For clinical evaluation of cancer genes, commonly used techniques include Sanger sequencing, mass spectrometry genotyping, fluorescence in situ hybridization (FISH) and immunohistochemical analysis (IHC). “Standard single marker detection” such as FISH, IHC and multi-gene hotspot detection (hotspot panel) can only find one or two types of clinically significant genetic abnormalities (such as only base substitutions). Studies have shown that the latest comprehensive next-generation sequencing technology for cancer comprehensive genetic testing can detect all four types of genetic abnormalities (base replacement; insertion and deletion; copy number variation and rearrangement), and is more accurate than traditional, standard tests.
Kako pacijenti s karcinomom mogu proći FoundationOne® CDx testiranje?
U Kini je to usluga analize koju pruža Dean Diagnostics. Globalna onkološka mreža može pomoći oboljelima od raka da prime ovu uslugu ili genetsko testiranje za domaću mjerodavnu potvrdu. Globalna mreža onkologa, kao poznata domaća platforma za pružanje usluga pacijentima s rakom, onkološki je centar i poznati stručnjaci za rak usko surađuju kako bi redovito organizirali tako velike sastanke razmjene liječnika i pacijenta i popularna znanstvena predavanja kako bi pomogli pacijentima da postanu standardizirani i autoritativni planovi dijagnoze i liječenja kroz stručne konzultacije u zemlji i inozemstvu te poboljšavaju stopu izlječenja. Također ćemo ustrajno nastojati neprestano uvoditi vodeće svjetske informacije o raku, tehnologiju, stručnjake, lijekove, klinička ispitivanja itd., I uložit ćemo sve napore kako bismo što većem broju pacijenata pružili bolje usluge protiv raka.
CancerFax kao poznata domaća platforma za savjetovanje i liječenje kod dijagnoze i liječenja raka, posvećena je pružanju prvoklasnih usluga protiv raka za domaće pacijente s rakom, uključujući najnoviju tehnologiju protiv raka i vrhunske stručne resurse, postavljajući najveći tumor savjetodavni i konzultantski centar u Indiji te surađujte s poznatim savjetodavnim centrima za tumore i stručnjacima iz Sjedinjenih Država, Kine, Izraela i Europe kako biste postali najpouzdaniji stručnjak za savjetovanje o dijagnozi i liječenju tumora na svijetu.
