Mingyang Song s Medicinskog fakulteta Harvard i Opće bolnice Massachusetts izvijestio je da će nakon dijagnoze nemetastatskog kolorektalnog karcinoma unos više vlakana smanjiti specifičnu smrtnost i ukupnu smrtnost od kolorektalnog karcinoma. Povećan unos vlakana nakon dijagnoze može koristiti pacijentima s karcinomom debelog crijeva. (JAMA Oncol. Internetska verzija 2. studenog 2017.).
Although it has been shown that high dietary fiber intake reduces the risk of colorectal cancer, it is not clear whether high fiber intake will benefit colorectal preživjele rak.
Kako bi se procijenila povezanost između unosa vlakana i smrtnosti, studija je obuhvatila 1575 bolesnika s karcinomom debelog crijeva od I do III iz dvije potencijalne skupine; nakon prilagodbe za ostale potencijalne prediktore preživljavanja od karcinoma, utvrđena je specifičnost kolorektalnog karcinoma. Mortalitet i ukupna smrtnost.
Između 6 mjeseci i 4 godine nakon dijagnoze raka debelog crijeva, istraživači su koristili validirani upitnik o učestalosti jedenja kako bi procijenili ukupan unos vlakana, količinu vlakana iz različitih izvora i količinu cjelovite pšenice.
Among the 1575 participants, 963 (61.1%) were women; the average age was 68.6 years. With a median follow-up of 8 years, 773 patients died, of which 174 died from colorectal cancer. A high total fiber intake after diagnosis is associated with a lower mortality rate. For every 5g increase in daily intake, the multivariable HR for colorectal cancer specific mortality and all-cause mortality were 0.78 (95% CI 0.65 ~ 0.93; P = 0.006) and 0.86 (95% CI 0.79 ~ 0.93) P <0 .001). According to fiber sources, cereal fiber can reduce kolorektalni cancer-specific mortality (for every 5 g / d increase in intake, HR = 0.67, 95% CI 0.50 ~ 0.90; P = 0.007) and all-cause mortality (HR = 0.78, 95% CI 0.68 ~ 0.90; P <0.001); vegetable fiber can reduce all-cause mortality (HR = 0.83, 95% CI 0.72 ~ 0.96; P = 0.009), but it does not reduce colorectal cancer-specific mortality (HR = 0.82, 95% CI 0.60 ~ 1.13; P = 0.22); No correlation was found between fruit fiber and mortality. Ingestion of whole wheat food can reduce the specific mortality of colorectal cancer (for every 20 g / d increase in intake, HR = 0.72, 95% CI 0.59 ~ 0.88; P = 0.002), but the correlation It will weaken after entry (HR = 0.77, 95% CI 0.62 ~ 0.96; P = 0.02).
