Agusta 2023: Don ciwon daji na launin fata (mCRC) wanda aka riga aka bi da shi tare da fluoropyrimidine, oxaliplatin, da irinotecan na tushen chemotherapy, maganin ilimin halittu na anti-VEGF, kuma idan RAS daji-nau'i, wani anti-EGFR far, Abinci da Drug Administration ya amince. trifluridine da tipiracil (LONSURF, Taiho Oncology, Inc.). LONSURF, maganin wakili guda ɗaya, ya riga ya sami izinin FDA don wannan amfani a cikin Satumba 2015.
A cikin SUNLIGHT (NCT04737187), bazuwar, lakabin buɗaɗɗe, multicenter, gwaji na duniya wanda ya kwatanta LONSURF tare da bevacizumab zuwa LONSURF guda ɗaya a cikin marasa lafiya 492 tare da ciwon daji na ciwon daji na metastatic wadanda suka sami matsakaicin tsarin maganin chemotherapy guda biyu kuma sun nuna ci gaban cutar su ko rashin haƙuri ga tsarin ƙarshe, aminci da inganci an kimanta.
Rayuwa gabaɗaya (OS) da tsira ba tare da ci gaba ba (PFS) sune mahimman ma'aunin sakamako na tasiri. Marasa lafiya da aka ba wa LONSURF ƙari bevacizumab hannun gwajin ya nuna haɓakar OS mai mahimmanci idan aka kwatanta da marasa lafiya da aka sanya wa hannun LONSURF (Hazard rabo 0.61; 95% CI: 0.49, 0.77; 1-gefe p0.001). Tsakanin OS na hannun LONSURF da bevacizumab shine watanni 10.8 (95% CI: 9.4, 11.8) kuma ga hannun LONSURF shine watanni 7.5 (95% CI: 6.3, 8.6). A cikin LONSURF da bevacizumab hannu, PFS na tsakiya shine watanni 5.6 (95% CI: 4.5, 5.9), yayin da a cikin hannun LONSURF, watanni 2.4 ne (95% CI: 2.1, 3.2) (Rashin haɗari: 0.44; 95% CI: 0.36, 0.54; 1-gefe p0.001).
Neutropenia, anemia, thrombocytopenia, gajiya, tashin zuciya, ƙara AST, ƙara ALT, ƙara yawan alkaline phosphatase, rage sodium, zawo, rashin jin daɗi na ciki, da rage cin abinci shine mafi yawan abubuwan da suka faru na gefe ko rashin daidaituwa na dakin gwaje-gwaje don LONSURF tare da bevacizumab (20%).
A ranakun 1 zuwa 5 da kwanaki 8 zuwa 12 na kowane zagayowar kwanaki 28, shawarar da aka ba da shawarar na LONSURF shine 35 mg/m2 ana sha da baki sau biyu a rana tare da abinci. Don cikakkun bayanai game da adadin bevacizumab, tuntuɓi bayanan da aka tsara.
Duba cikakken bayanin rubutawa don LONSURF.
