Appendic cancer is very rare, accounting for less than 1% of gastrointestinal tumors, and there is little scientific data on the disease, which means that the current guidelines for the treatment of colon cancer are recommended for patients with appendic cancer. To understand why some patients with appendix cancer respond to standard treatment for colon cancer, while others do not, the researchers performed a genetic analysis of 703 appendix cancer samples. This is by far the largest study of appendix cancer to compare the mutations present in the two cancer types.
Sakamakon binciken ya tabbatar da cewa maye gurbin kwayoyin halitta a cikin ciwon daji na appendix ya bambanta da na ciwon daji na hanji. Maye gurbi na TP53 da GNAS sune masu hasashen rayuwa a cikin marasa lafiya da ciwon daji na appendix. Ga cututtukan da ba safai ba, samun taswirorin kwayoyin halitta zai taimaka wajen tantance yuwuwar hanyoyin magani saboda ba mu da bayanan gwaji na asibiti don jagorantar daidaitaccen jiyya kamar sauran cututtukan daji. Hakanan mahimmanci, ana iya amfani da bakan maye gurbi a matsayin mai ƙididdigewa don bambance marasa lafiya masu haɗari waɗanda ke buƙatar kulawa mai zurfi don ware su daga marasa lafiya marasa haɗari.
Binciken binciken ya gano cewa abin da ya shafi kansa na daban-daban: Mucinous Adenocarco (kashi 46%), ƙwanƙwarar ƙwayar cuta (30%), kuma Signet). GNAS maye gurbi da ba kasafai ake samu ba a cikin ciwon hanji ya zama ruwan dare a cikin ciwon daji na appendix, musamman adenocarcinoma na mucinous (12%) da peritoneal pseudomyxoma (7.7%). Matsakaicin rayuwa na marasa lafiya tare da ciwace-ciwacen ƙwayoyi tare da maye gurbin GNAS kusan shekaru 5.2, yayin da matsakaicin rayuwa na marasa lafiya tare da ciwace-ciwacen ƙwayoyi tare da maye gurbi na TP52 shine kawai shekaru uku, kuma matsakaicin rayuwa na marasa lafiya ba tare da waɗannan maye gurbi guda biyu ba shine shekaru 72.
This surprising discovery raises the question of whether patients with early-stage GNAS-mutant tumors need to be treated with chemotherapy because it may be cured by surgery alone, so more research is needed to prove it.
