Hanyar gano cutar daji ta FoundationOne CDx (F1CDx) FDA ta amince da ita a cikin Nuwamba 2017 don gano nau'ikan kwayoyin halitta 324 daban-daban waɗanda zasu iya gano maye gurbi a cikin nau'ikan ƙari na 5 ciki har da rashin zaman lafiya na microsatellite (MSI) Tumor mutation load. Bugu da ƙari, nazarin taswirar kwayoyin Keruis ba zai iya yin gwajin kwayoyin halitta kawai ba (yawan kwayoyin halittar da aka gano shine 592), amma kuma yin gwajin furotin (CISH, pyrosequencing), gwajin MSI, da dai sauransu, abubuwan gwaji sun fi dacewa, da kuma maganin miyagun ƙwayoyi. zaɓi ya fi daidai.
Waɗannan gwaje-gwajen suna da fa'ida ga marasa lafiya tare da MSI mai girma (MSI-H) ko rashin daidaituwa na gyare-gyare (dMMR) marasa daidaituwa ko ciwace-ciwacen ƙwayar cuta, na iya karɓar pembrolizumab (Keytruda) kuma suna da fa'idodi masu mahimmanci. Ganowa kuma na iya gano wasu alamomin kwayoyin halitta da makasudi don jagorantar jiyya. Masu hana rigakafin rigakafi sun nuna wasu sakamako masu ban mamaki a cikin marasa lafiya da ciwon daji na ciki, musamman ciwon ciki na MSI-H. Ana ƙoƙarin ƙara yawan martanin masu hana wuraren bincike a cikin hanji da ciwon daji na pancreatic ta hanyar haɗin gwiwa. Masu bincike suna gudanar da bincike game da haɗuwa da magungunan rigakafi da yawa don fahimtar ko za su iya haifar da amsa a cikin ciwace-ciwacen da ba su da tasiri don maganin wakili guda ɗaya. An tsara gwaje-gwaje na asibiti, kuma a halin yanzu ana haɗa immunotherapy tare da chemotherapy da radiation far a ƙoƙarin inganta yawan amsawar waɗannan cututtuka.
Madaidaicin magani zai ƙara girma a cikin ƴan shekaru masu zuwa, ƙyale likitocin su gano alamomin halittu da maƙasudi fiye da fasahar zamani. Ta hanyar madaidaicin magani-gwajin kwayoyin halitta, ƙarin masu cutar kansa za su sami damar zaɓar mafi dacewa magungunan rigakafin cutar kansa don haɓaka ingantaccen magani, tsawaita rayuwa da haɓaka ingancin rayuwa.
http://www.onclive.com/web-exclusives/gastrointestinal-cancers-entering-age-of-precision-medicine?p=2
